六味消白方治疗白癜风疗效观察及机制研究

Study on Mechanism and Clinlical efficacy of the Six-flavor-eradicating vititligo prescription in Patients with Vitiligo

目的:观察六味消白方治疗白癜风的临床疗效并探讨其作用机制。方法:将63例白癜风患者随机分为治疗组和对照组,两组疗程均为3个月。同时采用双抗体夹心ELISA法测定两组患者治疗前后血清IL-18、IL-17的水平。结果:治疗组有效率为84.37%,痊愈率为37.50%,对照组有效率为51.61%,痊愈率为19.35%,两组比较有显著性差异(P<0.05)。治疗组血清IL-18、IL-17的水平治疗前较治疗后两者有显著性差异,对照组治疗前后血清中两者水平差异无显著性。结论:六味消白方治疗白癜风安全有效。六味消白方治疗白癜风可能通过抑制IL-18、IL-17而起治疗作用。

Objective：To investigate the mechanism and Clinlical efficacy of the Six-flavor- eradicating vititligo prescription in patients with vitiligo.Methods：63 vitiligo patients were randomly divided into two groups： 32 cases in experimental group and 31 cases in control group. The period of treatment in two group were 3 months. Enzyme-linked immunosorbent assy （ELISA） were used to detect the serum levels of IL-18 and IL-17 in two groups before and after treatment.Results：The effective rates of two groups were separately 84.37 % and 51.61% , and the healing rates of two groups were separately 37.50% and 19.35% ,there was significant difference between the two groups （P〈O.05）. The serum level of IL-18 and IL-17 in the experimental group was signifcanfly difference before and after treatment （P〈0.05）, while there is no significant difference between the indicators before and after treatment of the control group. Conclusion： Six-flavor- eradicating vititligo prescription is effective and well-tolerated in the treatment of vitiligo. The treatment effects of Six-flavor- eradicating vititligo prescription may he through its inhibiting effects on IL-18 and IL-17.