辛伐他汀对维持性血液透析患者氧化应激及微炎症状态的影响

Effects on Oxidative Stress and Microinflammation State of Simvastatin in Maintenance Hemodialysis Patients

目的探讨辛伐他汀对维持性血液透析(MHD)患者氧化应激及微炎症状态的影响。方法选择80例尿毒症血透患者分为两组,单纯血透组和辛伐他汀治疗组患者各40例,观察治疗前后血清中丙二醛(MDA),超氧化物歧化酶(SOD)和血清总抗氧化物能力(T-AOC)等氧化指标以及血清C-反应蛋白、白细胞介素-(6IL-6)、肿瘤坏死因子-α(TNF-α)等炎症指标的变化。结果研究组给予辛伐他汀治疗后,患者MDA、CRP、IL-6和TNF-α较治疗前和对照组明显降低(P<0.05),SOD活性、T-AOC活性较治疗前升高(P<0.05),而对照组治疗前后各项指标差异无统计学意义(P>0.05)。结论辛伐他汀能在一定程度上改善MHD患者的氧化应激和微炎症状态,且不良反应少,具有广泛的临床应用潜能。

Objective To explore the effects on oxidative stress and microinlfamma-tion state of Simvastatin in maintenance hemodialysis patients. Methods 80 patients with uraemia who underwent maintenance hemodialysis were divide into simple maintenance hemodialysis group（n=40）and Simvastatin group （n=40, and measured the serum concentrations of MDA, SOD,T-AOC, CRP,IL-6 and TNF-α, then these results was analyzed by statistical methods. Results The level of post-treatment serum MDA, CRP, IL-6 and TNF-αin the research group patients with Simvastatin were signiifcant lower than the prior treatment and the control group（P〈0.01）, and the level of serum SOD and T-AOC were signiifcant higher than the prior treatment and the control group（P〈0.01）. while the level of serum MDA, SOD,T-AOC, CRP,IL-6 and TNF-αin the control group between post-treatment and prior treatment have no statistical significance. Conclusion Simvastatin can alleviate oxidative stress and microinflammation state in maintenance hemodialysis patients, Furthermore, Simvastatin has fewer adverse reactions and a wide area of potential clinical applications.