金沸草散镇咳祛痰作用的研究

Study on the Antitussive and Expelling Phlegm Effects of Jinfeicao Powder

目的:考察金沸草散的镇咳、祛痰作用。方法:采用小鼠氨水致咳试验、小鼠二氧化硫引咳试验,观察其镇咳作用;采用小鼠酚红分泌试验及家鸽气管纤毛运动试验,观察其祛痰作用。结果:与模型组相比,金沸草散可显著延长氨水或二氧化硫引发小鼠咳嗽的潜伏期,并减少咳嗽次数(p<0.05或0.01);能增加小鼠呼吸道内酚红的排出量;并增加家鸽气管内墨水前进的距离。以上结果均具有统计学意义。结论:金沸草散具有明显的镇咳、祛痰作用。

Objective ： Studying on the antitussive and expelling phlegm effects of Jinfeicao Powder. Methods ： The effect on alleviating cough was observed in mice with ammonia water or sulfur dioxide induced cough. The effect on eliminating phlegm was evaluated by application of the phenol red secretion test to mice and the tracheal cilia exercise test to pigeon. Results： In compar ison with the control group, Jinfeicao Powder significantly prolonged the cough latency and decreased the cough frequency （p〈 O. 05 or O. O1 ） in mice with ammonia water or sulfur dioxide. Significantly, it increased the secretion of phenol red from mouse tracheas as well as increase the distance of ink moved in pigeon airway, The results were statistically significant. Conclusion： Jinfeicao Powder has significant effects of reliving cough and expelling phlegm.