SD大鼠血小板聚集实验测定方法的研究

Platelet Aggregation Test in SD Rats

目的建立SD大鼠血小板聚集实验的测定方法。方法用二磷酸腺苷（ADP）诱导大鼠的血小板聚集,测定其5min最大聚集率。结果 SD大鼠5min由ADP诱导的血小板最大聚集率95%可信区间为52%~76%。结论 SD大鼠的血小板聚集实验方法是一种快捷、有效、稳定性、重复性好的评价药效的方法。

Objective To establish a method for platelet aggregation test in SD rats.Methods Platelet aggregation was induced by ADP and 5minute maximum aggregation rate was measured in SD rats.Results The 95% confidence interval for 5minute maximum aggregation rate was 52%~76%.Conclusion The established platelet aggregation test is a quick,effective,stable and reproducible method for evaluating the pharmacological effect in SD rats.