急性脑梗死患者颈动脉粥样硬化与超敏C反应蛋白的关系研究

Relationship between Carotid Atherosclerosis and High-sensitivity C-reactive Protein in Patients with Acute Cerebral Infarction

目的探讨急性脑梗死患者颈动脉粥样硬化与血清超敏C反应蛋白(hs-CRP)的关系。方法选取急性脑梗死患者106例(研究组)和同期健康体检者60例(对照组),均进行颈动脉彩色多普勒超声检查,包括颈动脉内-中膜厚度(IMT)、有无颈动脉粥样斑块及其性质,同时检测血清hs-CRP水平。结果研究组IMT正常(n=14)、IMT增厚(n=21)和斑块形成者(n=71)hs-CRP水平均较对照组高(均P<0.05)。IMT正常、增厚、斑块形成者hs-CRP水平差异有统计学意义(均P<0.05),且两两比较差异均有统计学意义(P<0.05)。不稳定斑块患者(n=29)hs-CRP水平高于稳定斑块者(n=42)(P<0.05)。结论 hs-CRP作为炎性指标可能在促进动脉粥样硬化的发生和发展中发挥了重要作用,可反映颈动脉粥样硬化严重程度、脑梗死的患病风险及预后情况。

Objective To explore the relationship between high-sensitivity C-reactive protein（hs-CRP）and carotid atherosclerosis in patients with acute cerebral infarction.Methods The serum concentrations of hs-CRP were measured in 106patients with acute cerebral infarction and 60 healthy subjects.A color Doppler ultrasound system was used to determine carotid intima-media thickness（IMT）and carotid artery plaque.Results The levels of hs-CRP in healthy subjects were significantly lower than those in patients with normal IMT,increased IMT or plaque formation（P＆lt;0.05）.In addition,hs-CRP levels were significantly different among normal IMT group（n=14）,increased IMT group（n=21）and plaque formation group（n=71）（P＆lt;0.05）.In addition,hs-CRP levels in patients with unstable plaque（n=29）were significantly higher than those in patients with stable plaque（n=42）（P＆lt;0.05）.Conclusion As an inflammatory indicator,hsCRP may promote the occurrence and development of atherosclerosis.It can reflect the severity of carotid atherosclerosis and the risk and prognosis of cerebral infarction.