抗抑郁剂联合认知行为治疗抑郁症的疗效

Clinical Efficacy of Antidepressant Combined with Cognitive Behavior Therapy in Depression

目的探讨抗抑郁剂联合认知行为治疗抑郁症的临床疗效。方法将118例抑郁症患者按治疗方法的不同分为2组:观察组(60例)和对照组(58例)。2组患者均采用盐酸文拉法辛胶囊治疗。在此基础上,观察组患者采用认知行为治疗。观察2组患者治疗前,治疗后4、8及12周HAMD评分和治疗前,治疗后6、12周生活质量综合评定问卷(GQOLI-74)评分及临床疗效的情况。结果观察组总有效率显著高于对照组(83.3%比56.9%,P<0.05),观察组治疗后4、8及12周HAMD评分值均显著低于对照组(均P<0.05),观察组治疗后6、12周GQOLI-74评分值均显著高于对照组(均P<0.05)。结论抗抑郁剂联合认知行为治疗抑郁症可显著提高临床疗效,改善生活质量。

Objective To explore the clinical efficacy of antidepressant combined with cognitive behavior therapy in the treatment of depression.Methods A total of 118patients with depression were treated with venlafaxine hydrochloride capsules（control group,n=58）or in combination with cognitive behavior therapy（observation group,n=60）.HAMD scores were compared between the two groups before treatment and 4,8and 12weeks after treatment.In addition,comprehensive assessment of the quality of life questionnaire（GQOLI-74）scores and clinical efficacy were compared between two groups before treatment and 6and 12weeks after treatment.Results The total effective rate in observation group was significantly higher than that in control group（83.3% vs 56.9%,P＆lt;0.05）.Moreover,cognitive behavior therapy induced a decrease in HAMD scores at 4,8and 12weeks after treatment and an increase in GQOLI-74scores at 6and 12weeks after treatment compared with control group（P＆lt;0.05）.Conclusion Antidepressant combined with cognitive behavior therapy can improve the curative effect and enhance the quality of life in patients with depression.