摘要
目的:揭示香砂六君子汤水煎液活性成分的化学物质基础,对其进行系统的化学成分研究。方法:按传统煎煮方法提取,反复运用硅胶柱色谱、Sephadex LH-20进行分离,并通过波谱分析进行结构鉴定。结果:分离并鉴定了9个化合物,分别为白术内酯Ⅱ(atractylenolideⅡ,1)、去氢木香内酯(dehydrocostus lactone,2)、白术内酯Ⅰ(atractylenolideⅠ,3)、白术内酯Ⅲ(atractylenolidⅢ,4)、芒柄花黄素(formononetin,5)、丁二酸(succinic acid,6)、柠檬苦素(limomin,7)、蜜桔黄素(nobiletin,8)、4',5,7,8甲氧基黄酮(tetramethyl-o-isoscutellarein,9)。结论:这9个化合物均首次从该方中分离得到。
Objective:To explore Xiangsha Liujunzi water decoction of Ethyl acetate parts solution active ingredients of chemical material foundation,carries on the comprehensive development and utilization,the chemical composition of the system research.Method:According to the traditional decoction method extraction,repeatedly using silica gel column chromatography,sephadex LH-20 and through the spectrum analysis structure identification.Result:Separation and identification of 9 compounds,rhizoma atractylodis macrocephalae lactone Ⅱ respectively (atractyIenolide Ⅱ,1),hydrogen radix aucklandiae lactone (dehydrocostus lactone,2),rhizoma atractylodis macrocephalae lactone Ⅰ (atractylenolide Ⅰ,3),rhizoma atractylodis macrocephalae lactone Ⅲ (atractylenolid Ⅲ,4),formononetin (formononetin,5),succinic acid (succinic acid,6),limonin (limomin,7),orange flavin (nobiletin,8),4',5 proposal methoxyl yellow ketone (tetramethyl-o-isoscuteIlarein,9).Conclusion:The 9 compounds were isolated from the party for the first time to get.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第20期112-114,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
重庆市科委重点项目(CSTC2010AC5095)
四川省教育厅重点课题(09ZA028)
四川省教育厅重点课题(10ZA095)
成都市科技局科技攻关项目(10GGYB303SW-023)
成都中医药大学校基金重点课题(ZRZD201101)
关键词
香砂六君子汤
水煎液乙酸乙酯部位
化学成分
Xiangsha Liujunzi tang
water decoction solution acetic ester parts chemical composition
chemical constituents