3种口尝评价方法用于药物苦度评价的比较

Drug Evaluation of Bitterness Intensity by Three Kinds of THTPM

目的:对比3种口尝评价方法用于药物苦度评价研究的特点。方法:以苦参碱为模型药物,配制成不同浓度的水溶液,由20名经筛选、培训合格的评价员口尝测试其苦度等级及具体苦度值,对样品进行排序法、评分法、排序结合评分法3种方法的评价,经过对所得数据的处理,用排序正确率、判断灵敏度、赋值精密度、拟合度4个指标综合分析。结果:排序结合评分法的排序正确率为100%,判断灵敏度为96.4%,拟合方程复相关系数为0.991 6,3个指标均优于其他2种方法;评分法在赋值精密度方面较其他2种方法更优。结论:3种口尝方法就上述4个指标来看数排序结合评分法最优,但各有自己的特点,具体的口尝方法可根据自己实验目的、样品数目等选择。

Objective：Compare characteristics of three kinds of THTPM （traditional human taste panel method） which is suitable for drugs bitter evaluation study.Method：As matrine a model drug,made into different concentration of aqueous solution.The training of qualified evaluators screened by 20 taste bitterness level,then make specific bitterness value.Three methods of evaluation of the sample were order evaluation methods,score evaluation method and integrated score evaluation method.After the data processing,comprehensive analysis of the four indicators integrate which was rate of right rank,decision sensitivity,precision of evaluate and fitting of degree.Result：Integrated score evaluation method whose rate of right rank was 100％,decision sensitivity was 96.4％,multiple correlation coefficient of Fitting Degree was 0.9916 which is superior to other two methods through the three indicators.Moreover the score evaluation method was better than the other two methods in precision of evaluate.Conclusion：Integrated score evaluation method in the three methods of the tasting evaluation is the best though these four numbers of the indicators.But different experiment methods have its characteristics.Concrete tasting evaluation method is selected on the basic of the purpose of the experiment,the number of the sample and so on.