固本平喘汤治疗支气管哮喘慢性持续期48例

Guben Pingchuan Decoction Treatment on 48 Cases of Chronicity-persistent Period in Bronchial Asthma

目的:观察固本平喘汤治疗支气管哮喘慢性持续期的临床疗效。方法:将96例患者随机按数字法分为观察组和对照组。两组均参照"支气管哮喘防治指南(2008)"进行常规治疗,观察组加用固本平喘汤,1剂/d,疗程均为12周。进行治疗前后哮喘控制测试(ACT)评分,肺功能用力呼气量(FEV1),用力肺活量(FVC),呼气流速值(PEF)评价,哮喘症状评分,生活质量评价及中医肺肾气虚、寒痰内伏证评分。结果:观察组治疗有效率93.75%优于对照组的77.08%(P<0.05);观察组ACT各单项评分及总分均高于对照组(P<0.01);观察组肺功能(FEV1,FVC,PEF)的改善均优于对照组(P<0.01);观察组哮喘日间症状和夜间症状评分评分低于对照组(P<0.01);观察组圣乔治呼吸问卷(SGRQ)各项评分均明显下降并低于对照组(P<0.01);观察组肺肾气虚、寒痰内伏证评分低于对照组(P<0.01)。结论:固本平喘汤能改善支气管哮喘慢性持续期患者临床症状,提高生活质量,临床疗效高,值得推广使用。

Objective：To investigate the effect of Guben Pingchuan decoction treatment of chronicitypersistent period in bronchial asthma.Method：Niety-six patients were randomly allocated into observational group and control group,48 cases in each.With the reference of bronchial asthma prevention and treatment guidelines （2008） for conventional treatment,the observation group was treated with Guben Pingchuan decoction,1 times/day,lasting for 12 weeks.Pre and post the treatment,asthma control test （ACT） scores,lung function forced expiratory volume in one second （FEV1）,forcedvitaclcapacity （FVC）,expiratory flow ratel （PEF）,asthma symptom score,quality of life assessment and symptom scales of lung and kidney Qi deficiency with cold phlegm were measured.Result：The effectiveness of observation group was 93.75％,better than the control group with 77.08％ （P ＜ 0.05）.Each domain and overall items of ACT of observation group were higher than the control group （P ＜0.01）.The improvement of lung function （FEV1,FVC,PEF） of the experimental group was better than of the control group （P ＜ 0.01）.Asthma symptoms of daytime and nighttime symptom score rating of the experimental group was lower than that of the control group （P ＜ 0.01）.The St.George ＇s Respiratory Questionnaire （SGRQ） scores of the experimental group,were significantly decreased and lower than that of the control group （P ＜0.01）.The scores of Lung and kidney Qi deficiency with Cold phlegm syndrome were lower than the control group （P ＜0.01）.Conclusion：Guben Pingchuan decoction improves the clinical curative effect and patients life quality of chronicity-persistent period in bronchial asthmaand deserves promotion.