热毒宁注射液静脉滴注和雾化吸入治疗毛细支气管炎45例

Reduning Injection and Atomization Inhalation Treatment of Bronchiolitis in 45 Cases

目的:探讨热毒宁注射液静脉滴注和雾化吸入治疗小儿毛细支气管炎的临床疗效及对炎性因子的影响。方法:90例患儿随机按数字法分为观察组和对照组各45例。两组患儿均在西医常规处理的基础上,对照组采用布地奈德1 mg及特布他林5 mg加入生理盐水5 mL中通过氧气驱动雾化吸入;观察组采用热毒宁注射液静脉点滴及氧气驱动雾化吸入。疗程均为7 d。于第0、3天记录动脉血气指标;于第0、3、7天记录主要症状、体征;检测治疗前后血清白介素-8(IL-8),白介素-6(IL-6),肿瘤坏死因子-α(TNF-α)水平。结果:观察组总有效率95.6%优于对照组的82.2%(P<0.05);第3天观察组血氧饱和度(SPO2),氧分压(PaO2)均明显升高且高于对照组,PaCO2下降且低于对照组(P<0.01);第3天观察组发热、咳嗽、咯痰、喘憋及肺部听诊评分低于对照组(P<0.01);第7天,观察组咳嗽、咯痰、喘憋及肺部听诊评分低于对照组(P<0.01);观察组血清IL-6,IL-8及IFN-α水平均低于对照组(P<0.01)。结论:采用热毒宁注射液静脉和雾化吸入治疗小儿毛细支气管炎临床疗效显著,作用机制可能与其减轻炎症反应相关。

Objective：To discuss the clinical efficacy of treating pediatric capillary bronchitis with Reduning injection intravenous drip and Inhalation extra and the influence to inflammatory factors.Method：Ninety patients with pediatric capillary bronchitis were randomly divided into observation group （n =45） and control group （n =45）.Patients in the two groups were both treated with conventional Western therapy.Patients in control group were treat with budesonide 1 mg and terbutaline 5 mg in physiological saline 5 mL by oxygen atomizing inhalation.Patients in observation group were given reduning injection intravenous drips and oxygen atomizing inhalation.Both groups were taken 7 day one cycle.The arterial blood gas index were recorded at 0 d and 3 days and the main symptoms and signs were recorded at 0,3,7 day; Serum interleukin-8 （IL-8）,interleukin-6 （IL-6）,tumor necrosis factor-α （TNF-α） levels were tested before and after treatment.Result：The total efficacy of the observation group 96.6％ was significantly better than the control group 82.2％ （P ＜ 0.05）.Oxygen saturation （SPO2） and oxygen tension （PaO2） were both significantly higher at 3 day and observation group was higher than control group.PaCO2 of observation group was decline and was lower than control group （P ＜0.01）.At 3 day,fever,cough,expectoration,wheezing suppress and lung auscultation score of observation group were lower than control group （P ＜0.01）.At 3 day,cough,expectoration,wheezing suppress and lung auscultation score of observation group were lower than control group （P ＜ 0.01）.Serum IL-6,IL-8 and TNF-αlevels of observation group were lower than control group （P ＜ 0.01）.Conclusion：Reduning injection intravenous micropump and inhalation extra has significant clinical efficacy and the mechanism may be related to reduce inflammation.