基质金属蛋白酶与AS血管重构的关系及中药逆转作用的研究进展

Relationship between Matrix Metalloproteinase and AS Vascular Remodeling and Reversal Effect of Traditional Chinese Medicine

通过查阅文献,发现多种中药单体和复方均能调节动脉粥样硬化(AS)过程中基质金属蛋白酶(MMPs)的表达,达到抗AS的作用,作者对MMPs的生物学特性、致病机制以及中医药的逆转作用进行整理分析,以期为寻找有效的防治AS的中药提供帮助。血管重构(VR)的核心病变是平滑肌细胞的增殖、迁移、凋亡以及基质成分的合成、降解及重新排列等过程。从中医辨证角度考虑,中药的多靶点、多作用途径的特点为其开发提供了帮助的同时也为中药的研究带来了困难。针对其特点,具体的、有针对性的AS中医模型有待开发,同时,中药单体的提取以及药物药理的作用仍要研究,应充分发挥中西医的辨病与辨证相结合进行选药的原则,将中医宏观证型与现代医学的微观辨病有机的结合在一起,充分发挥中医药治疗AS的作用。

Atherosclerosis is a common pathological basis of cardiovascular disease.The pathological changes of smooth muscle cell and extracellular matrix metalloproteinases led to vascular remodeling.The key factors of causing and maintaining atherosclerosis plaque vulnerability.Matrix metalloproteinases play an important role.This article reviews the biological characteristics and pathogenic mechanism of matrix metalloproteinases and the reversal effect of traditional Chinese medicine （TCM） in order to provide help to search for effective TCM of atherosclerosis.