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基于LC-MS-代谢组学技术在慢性肾脏病的应用

LC- MS- based metabolomics and its application for chronic kidney diseases
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摘要 基于液相色谱-质谱(LC-MS)联用技术的代谢组学已应用于不同的研究领域,该技术在慢性肾脏病的动物模型和临床应用取得了一定的进展。本文评述了基于LC-MS联用技术的代谢组学在慢性肾衰竭、尿毒症、IgA肾病、慢性肾小球肾炎、糖尿病肾病等应用进展。 Liquid chromatography-mass spectrometry （LC-MS）-based metabolomical techniques have been applied to different fields and significant progresses have been achieved in the metabolic profiling of different chronic kidney diseases in animal models and clinical trials.This review article presented an overview of the recent developments in the field of LC-MS-based metabolomics for chronic renal failure,uremia,IgA nephropathy,chronic glomerulonephritis,diabetic nephropathy,etc.
作者 冯亚龙 赵英永 林瑞超
机构地区 西北大学生命科学学院 中国食品药品检定研究院
出处 《药物分析杂志》 CAS CSCD 北大核心 2013年第10期1811-1815,共5页 Chinese Journal of Pharmaceutical Analysis
基金 国家自然科学基金(81001622) 长江学者和创新团队发展计划(IRT1174) 陕西省国际合作项目(2013KW31-01)
关键词 代谢组学 液相色谱 质谱 慢性肾衰竭 尿毒症 IGA肾病 糖尿病肾病 生物标示物 综述 metabolomics liquid chromatography mass spectrometry chronic renal failure uremia IgA nephropathy diabetic nephropathy biomarker review
分类号 R917 [医药卫生—药物分析学]
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参考文献41

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药物分析杂志
2013年 第10期

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