血清抵抗素在急性胰腺炎中的变化

Prognostic values of serum resistin in patients with acute pancreatitis

目的 探讨血清抵抗素在急性胰腺炎中的动态变化及其在病情判断中的意义.方法 酶联免疫吸附试验（ELISA）法动态检测48例急性胰腺炎患者的血清抵抗素水平,并通过在受试者工作特征曲线（ROC）上选择1个截断点,得到预测急性胰腺炎病情的血清抵抗素临界值.另设30例年龄、性别与体质量指数相匹配的健康体检者作为对照.结果 急性胰腺炎组入院时血清抵抗素含量[（4.09±1.45） mg/L,24 h内]较健康对照组[（0.87 ±0.34） mg/L]明显升高（t=20.85,P＜0.01）,随病情变化于发病后3～7d出现逐渐降低、持续高值或继发性升高；重症急性胰腺炎组血浆抵抗素[（6.73 ±2.46） mg/L]含量均明显高于急性水肿型胰腺炎组[（2.68±1.07） mg/L,t =9.84,P＜0.01）；根据ROC曲线初步得出血清抵抗素浓度高于4.81 mg/L可预测急性胰腺炎病情.结论 血清抵抗素水平变化与急性胰腺炎患者病情密切相关.

Objective To investigate the dynamical changes and prognostic values of serum resistin in patients with acute pancreatitis.Methods The serum concentration of resistin in 48 patients with acute pancreatitis and 30 healthy subjects were dynamically determined by using enzyme linked immunosorbent assay （ELISA）.By selecting a cut-off point in the receiver operating characteristic （ROC） curve,a specific concentration of serum resistin for prognosis of acute pancreatitis was estimated.Results The serum concentration of resistin on admission in study group [（4.09 ± 1.45） mg/L within 24 h] was significantly increased as compared with that in control group [（0.87 ±0.34） mg/L,t =20.85,P ＜0.01],and during 3rd to 7th day gradually reduced,mainained a high level or secondary increase following the changes in the disease conditions.As compared with the acute edematous pancreatitis group [（2.68 ± 1.07） mg/L],the levels of serum resistin within 24 h were significantly increased in severe acute pancreatitis group [（6.73 ± 2.46） mg/L] （t =9.84,P ＜0.01）.According to ROC curve,serum resistin concentration ＞ 4.81 mg/L was indicated to predict disease conditions of patients with acute pancreatitis.Conclusion The changes of serum resistin are associated with the disease conditions of patients with acute pancreatitis.