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ret/PTC3基因重排在甲状腺癌中的作用机制及其研究进展 被引量：9

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摘要 甲状腺癌是人体常见的内分泌系统肿瘤,健康人群中甲状腺结节的发病率为20％ ～ 76％[1].其中5％～15％为甲状腺癌[2].2010年来,美国化学学会（ACS）统计数据表明甲状腺癌发病率已经成为女性恶性肿瘤的第5位.ret/PTC3基因重排在甲状腺癌发生发展过程关系密切,现就其研究进展作一综述.
作者 王波 赵文新
机构地区 福建医科大学附属协和医院血管甲状腺外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2013年第10期2241-2242,共2页 Chinese Journal of Experimental Surgery
基金 福建省教育厅科技资助项目（JB11061） 福建省自然科学基金资助项目（2012J01355） 国家临床重点专科建设资助项目
关键词 甲状腺癌 基因重排 内分泌系统肿瘤 女性恶性肿瘤 癌发病率 甲状腺结节 健康人群 数据表
分类号 R736.1 [医药卫生—肿瘤]
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参考文献22

  • 1Gharib H,Papini E,Paschke R,et al.American Association of Clinical Endocrinologists,Associazione Medici Endocrinologi,and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules:executive summary of recommendations.J Endocrinol Invest,2010,33:51-56.
  • 2Cooper DS,Doherty GM,Haugen BR,et al.Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.Thyroid,2009,19:1167-1214.
  • 3Takahashi M,Ritz J,Cooper GM.Activation of a novel human transforming gene,ret,by DNA rearrangement.Cell,1985,42:581-588.
  • 4Pasini B,Hofstra RM,Yin L,et al.The physical map of the human RET proto-oncogene.Oncogene,1995,11:1737-1743.
  • 5盖宝东,森隆弘,膝盛启成,大内宪名,里见进,张德恒,郑泽霖.散发型甲状腺髓样癌酪氨酸激酶受体基因第918位点基因突变及意义[J].中华实验外科杂志,2006,23(3):319-321. 被引量：1
  • 6Fusco A,Grieco M,Santoro M,et al.A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases.Nature,1987,328:170-172.
  • 7Sassolas G,Hafdi-Nejjari Z,Ferraro A,et al.Oncogenic alterations in papillary thyroid cancers of young patients.Thyroid,2012,22:17-26.
  • 8Nikiforov YE.Thyroid carcinoma:molecular pathways and therapeutic targets.Mod Pathol,2008,21:S37-S43.
  • 9Musholt TJ,Mushoh PB,Khaladj N,et al.Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma.Surgery,2000,128:984-993.
  • 10Besset V,Scott RP,Ibanez CF.Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.J Biol Chem,2000,275:39159-39166.

二级参考文献18

  • 1李尹雄 卢圣栋 主编.核酸的分离与纯化[A].卢圣栋，主编.现代分子生物学实验技术:第2版[C].北京:中国协和医科大学出版社,1999.102-104.
  • 2Klugbauer S, Pfeiffer P, Cassenhuber H. RET rearrangement in radiation induced papillary thyroid carcinoma: High prevalence of topoisomerase I sites at breakpoints and micro homology mediated end joining in ELE1 and RET chimeric genes [J]. Genomics, 2001,
  • 3Imanaka T. Recent research activities about the Chernobyl NPP accident in Belarus, Uklarus and Russia [C] . Japan:Research Reactor Institute, Kyoto University, 2002. 240.
  • 4Tuttle RM, Becker DV. The Chernobyl accident and its consequences: update at the millennium [J]. Semin Nucl Med, 2000, 30(2): 133-140.
  • 5Zimmerman D. Thyroid neoclassic in children[J]. Curr Opin Pediatr, 1997, 9(4): 413-418.
  • 6Igor A, Imanaka T. Legislation and research activity in russia about the radiological consequences of the Chernobyl accident[J]. Health Phys, 1997, 32(2): 211-225.
  • 7Pisarchik AV, Ermak G, Kartel NA. Molecular alterations involving p53 codons 167 and 183 in papillary thyroid carcinomas from chernobyl-contaminated regions of belarus[J].Thyroid, 2000, 10(1): 25-30.
  • 8Rabes HM. Gene rearrangements in radiation-induced thyroid carcinogenesis[J]. Med Pediatr Oncol, 2001, 36(5):574-582.
  • 9Schilling T,Burck J,Sinn HP,et al.Prognostic value of codon 918(ATG→ACG) RET proto-oncogene mutations in sporadic medullary thyroid carcinoma.Int J Cancer,2001,95:62-66.
  • 10Eng C,Mulligan LM,Smith DP,et al.Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma.Genes Chromosomes Cancer,1995,12:209-212.

共引文献21

同被引文献130

  • 1Riley LB,Desai DC.The molecular basis of cancer and the development of targeted therapy[J].Surg Clin North Am,2009,89(1):1-15.
  • 2Chua EL,Young L,Wu WM,et al.Cloning ofTC-1 (C8orf4),a novel gene found to be overexpressed in thyroid cancer[J].Genomics,2000,69 (3):342-347.
  • 3Jung Y,Bang S,Choi K,et al.TC1 (C8orf4) enhances the Wnt/betacatenin pathway by relieving antagonistic activity of Chibby[J].Cancer Res,2006,66(2):723-728.
  • 4Mokhtarzada S,Yu C,Brickenden A,et al.Structural characterization of partially disordered human Chibby:insights into its function in the Wnt-signaling pathway[J].Biochemistry,2011,50 (5):715-726.
  • 5Kim B,Koo H,Yang S,et al.TC1 (C8orf4) correlates with Wnt/betacatenin target genes and aggressive biological behavior in gastric cancer[J].Clin Cancer Res,2006,12 (11 Pt 1):3541-3548.
  • 6Bednurek AK,KJ , Daniri HI., el al. WWOX , a novel WW do-main-[M]ntaining protein mapping to human chmnmsomc 16q23. 3-24. 1,a region frequenlly affected in breast cancer[ J] . Causer Res,2000,60(8) :2140-2145.
  • 7Zhang M,Kong I.,Cui Z,el al. The WWOX gene inhibits tlu> grmvthof U266 multiple myeloma cells by Irigering tlie intrinsic aimptolirpathway [j]. Ini J Mod Med ,2014 .34(3 ) :804-809.
  • 8Nowakowska M, Pospiech K, Ix'wandowska U , et al. DiverseofWWOX overexpif;ssion in Hl^ and SW480 (-.lon cancer cell lines[J]. Tumour Bin] ,2014,35(9) : 9291-9301.
  • 9Zhang H,Tian Y ,Shen J ,et al. Upregulation of the putative (.nc?geueCOTK1 contrihutes to hunian hepalocarcinogenesis llirough modulationof WWOX signaling[J]. Int J Oncol ,2014 ,45 (2) :719-731.
  • 10Zeng H,Kong X ,IVng H,et al. Apoptosis and hcl-2 family proteins,laken to chronk. obslructive bulmonarv disease [ J ]. Eur liev MedPhannafol Sci,2012,16(6) :711 -727.

引证文献9

二级引证文献63

中华实验外科杂志
2013年 第10期

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