Cs_2CO_3催化三组分“一锅法”合成5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-腈衍生物

Cs_2CO_3-Promoted One-Pot Three-Component Synthesis of 5-Amino-7-aryl-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidine- 6-carbonitrile Derivatives

在Cs2CO3催化下,以3-氨基-1,2,4-三唑、芳香醛、丙二腈为原料,经三组分一锅法合成了一系列5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-腈衍生物.利用1H NMR,IR,MS对产物进行了结构表征.该方法具有操作简单方便、产率优良等优点.

A series of 5-amino-7-aryl-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile derivatives were synthesized by three-component one-pot reaction of 3-amino-1,2,4-triazole, aryl aldehyde and malononitrile in the presence of Cs2CO3 as a catalyst. All target compounds were characterized by IH NMR, IR and MS techniques. The advantages of this method are simple, convenient and improved yields.