近年活性维生素D类似物的合成进展概况

Recent Progress in the Syntheses of Active Vitamin D Analogues

简要地叙述了近年来对某些C2-取代、19-去亚甲基、C2-取代-19-去亚甲基-1α,25-二羟维生素D3类似物、C22-氧杂-1α,25-二羟维生素D3类似物、C20位具有二个边链-1α,25-二羟维生素D3类似物、维生素D受体拮抗剂、去C,D环-维生素D类似物的设计和合成以及其构象与生物活性的关系.

Based on la,25-dihydroxyvitaminD3 exhibits its also regulates cell growth, differentiation, antiproliferation, critical role in regulating calcium and phosphorus homeostasis, apoptosis, and immunomodulation. This review concisely de- scribes some of the current frontiers of vitamin D research in the design and syntheses of the analogs of C2-substituted-, 19-nor-, C2-substituted-19-nor-la,25-dihydroxyvitamin D3 （125D）, C22-oxa-125D, Gemini vitamin D analogs, VDR-antago- nists （Vitamin D receptor）, des-C,D-19-nor-125D and the relation between the conformations and the biological activities.