去纤酶对冠状动脉成形术后再狭窄和心脏负荷能力的影响

Effects of Defibrase on Restenosis and Heart Stress Capability after Percutaneous Transluminal Coronary Angioplasty

本研究旨在评价去纤酶对冠状动脉成形术 (PTCA)后再狭窄及心脏负荷能力的影响。方法 :142例PTCA术后患者随机进入去纤酶组 (n =70 )和肝素组 (n =72 ) ,术后分别用去纤酶及肝素治疗 ,分别于PTCA前、PTCA后 7～ 14天、3～ 6个月和 10～ 12个月进行心电图运动试验及核素心肌灌注显像负荷试验 ,可疑再狭窄者行冠状动脉造影。PTCA后 2组患者最大运动时间、心率指数、ST段缺血指数及心肌血流灌注均较PTCA前明显改善 ,但去纤酶组的改善程度较肝素组更显著 (P均 <0 .0 5)。去纤酶组及肝素组的再狭窄率分别为 11%和 2 1% (P >0 .0 5)。去纤酶能显著改善PTCA术后心肌血流灌注和心脏负荷能力 。

To evaluate the effects of defibrase on restenosis and heart stress capability after percutaneous transluminal coronary angioplasty(PTCA).Methods:One hundred and forty two patients were randomized into group A( n =70)and group B( n =72),which were treated with defibrase and heparin after PTCA,respectively.Treadmill exercise electrocardiography and stress nuclear myocardiotomography were undergone before PTCA,at 7～10 day,3～6 month and 12 month after PTCA,respectively.Coronary angiography was taken in patients with suspicious restenosis.Results:Comparing with before PTCA,the maximal exercise time,heart rate index,ST segment ischemic index,and myocardial perfusion were significant improved at each stage after PTCA in both groups( P <0.05 or 0.01) ,but the improvement was greater in group A than in group B( P <0.05).The rates of restenosis were 11% in group A and 21% in group B respectively( P >0.05).Conclusion:Defibrase can improve myocardial perfusion and heart stress capability and maybe decrease restenotic rate in patients after PTCA.