脑出血患者血浆和颅内血肿液中VIP、CGRP含量的研究

The Changes of Vasoactive Intestinal Peptide and Calcitonin Gene Related Peptide in Venous Plasma and Hematoma Fluid in Patients with Cerebral Haemorrhage

测定脑出血患者静脉血浆和颅内血肿液中血管活性肠肽 (VIP)、降钙素基因相关肽 (CGRP)含量的变化 ,发现脑出血患者静脉血浆VIP含量无显著改变 ,颅内血肿液VIP含量显著低于静脉血浆VIP含量 ;脑出血患者静脉血浆CGRP含量显著高于对照组 ,不同时期 ( <6h ,6h～ 72h ,>72h)血浆及颅内血肿液CGRP含量比较 ,<6h含量最高 ,此后呈下降趋。本研究结果表明 ,VIP和CGRP参与了脑出血后脑循环改变的病理生理过程 。

The levels of vasoactive intestinal peptide(VIP) and calcitonin gene related peptide(CGRP) were assayed in venous plasma and hematoma fluid in patients with cerebral haemorrhage.The levels of VIP in venous plasma did not differ between the patients and controls,but VIP in hematoma fluid was lower than that in venous plasma.The plasma CGRP contents in patients were significantly higher than those in control group,CGRP levels in plasma and hematoma fluid were compared in different stages(<6h,6h～72h,>72h),the highest levels were detected in <6h,then the levels of CGRP had a tendency to decrease after 6h.The results suggest that VIP and CGRP may be involved in the pathophysiological procedures of cerebral circulation after haemorrhage,particularly in local brain injury at initial occupying.