和平散对消炎痛致大鼠胃粘膜损伤的保护作用

The Protective Action of Heping Powder on Indomethacin -Induced Gastric Mucosal Damage in Rats

观察和平散对消炎痛所致大鼠胃粘膜损伤的保护作用 ,采用肌肉注射消炎痛 ( 2 0mg/kg)胃粘膜损伤模型 ,观察和平散 (潞党参、五味子、陈皮等 ) 3个剂量组和对照组的损伤指数 ,并同时检测血清和胃组织匀浆的超氧化物歧化酶 (SOD)活力和丙二醛 (MDA)含量。结果发现和平散各剂量组的胃粘膜损伤指数均较对照组明显减轻 (P <0 0 1及P <0 0 0 1) ,且具有剂量依赖性 ,三倍量组的抑制率达 94 % ;和平散可明显提高血清和胃组织的SOD活力 ,降低其MDA含量。说明和平散可显著抑制消炎痛所致胃粘膜损伤 ,其作用机制可能与抗氧化损伤有关。

To investigate the protection of Heping powder on indomethacin-induced gastric mucosal damage,we established the indomethacin(20mg/kg) induced-gastric mucosal damage model in rats,and compared the lesion index of Heping powder(3 dosages) groups and control group.Superoxide dismutase(SOD) and malonic aldehyde(MDA) levels in blood and gastric tissue homogenate were measured as well.Results showed that the gastric mucosal lesion indexes of all Heping powder groups were abated(P<0 01～0 001),the inhibitory rate of the triple dosage groups was highest (94%).It is indicated that action of Heping powder shows a dose-dependent relationship.Heping powder can increase SOD activity and decrease MDA content as well.Heping powder also can inhibit gastric mucosal damage induced by indomethacin,the mechanism may be associated with antioxidation.