冠通Ⅰ号对实验性兔动脉粥样硬化的影响

The effect of NO.1 Guantong on the experimental atherosclerosis of rabbit

目的 观察冠通Ⅰ号对实验性兔动脉粥样硬化的作用。方法 新西兰大白兔 30只 ,随机分为对照组 (普通颗粒饲料 )、高胆固醇组 (普通颗料饲料 + 1.5 %胆固醇 )、药物干预组 (普通颗粒饲料 + 1.5 %胆固醇 +冠通Ⅰ号 1.0g/kg·d)。实验前及实验后 9周 ,测定各组兔血清脂质、前列腺素I2 、血栓素B2 及观察主动脉病理学改变。结果 实验前各组兔血清总胆固醇 (TC)、甘油三脂 (TG)、低密度脂蛋白胆固醇 (LDL C)、血浆血栓素BC(TXB2 )、6 酮 前列环素F1α(6 keto PGF1α)均无统计学差异 (P >0 .0 5 )。实验 9周后 ,高胆固醇组、药物干预组血清TC、TG、LDL C及血浆TXB2 、TXB2 / 6 keto PGF1α比值均高于对照组 (P <0 .0 5 ) ,但药物干预组低于高胆固醇组 (P <0 .0 5 )。病理切片发现 :药物干预组兔主动脉粥样硬化程度较高胆固醇组兔主动脉粥样硬化程度轻。结论 冠通Ⅰ号具有调整脂质代谢、抗血小板。

Objective To study the effect of NO.1 Guantong on the experimental atherosclerosis of cholesterol fed rabbit, Methods 30 New Zealand rabbits were randomly divided into 3 groups, control group (general food), high dose cholesterol group (general food plus 1.5% cholesterol), herb treatment group (general food plus 1.5% cholesterol and NO.1 Grantong).Serum TC、TG、HDL C、plasma TXB 2 and 6 keto PGF 1α were measured in 3 groups. LDL C was calculated by Friedwaid formula. Result Serum TC、TG and LDL C level were lower in Herb treatment group than High dose cholesterol group ( P <0.05) plasma TXB 2 and TXB 2/6 keto PGF 1α ratio were lower in Herb treatment group than High dose cholesterol group ( P <0.05). Serum HDL C Level and plasma 6 keto PGF 1α were similar in 3 groups ( P >0.05), but serum TC、TG、LDL C、TXB 2 and TXB 2/6 keto PGF 1α ratio were higher in Herb treatment group and High dose cholesterol group than control group . Conclusion No.1 Guantong regulates the lipid metablism and have a antiplaelet function. NO.1 Guantong can prevent the progression of atherosclerosis in chloes terol fed rabbit.