恶性淋巴瘤乙肝病毒血清标志阳性患者肝损害336例临床分析

Clinical observation of hepatic injury in lymphoma patients with positive serum label of hepatitis B virus

目的 观察乙肝病毒血清标志 (HBVM)阳性淋巴瘤患者化疗所致肝功能损害情况。方法 HBVM阳性淋巴瘤患者 336例 ,化疗 2周后测肝功能 ,包括ALT、AST、ALP、GGT及TBIL ,对照组为 119例HBVM阴性淋巴瘤患者。结果 HBVM阳性组肝功能异常占 38.39% ,显著高于对照组 19.33 % ,(P <0 .0 1)。

Objective To observe the hepatic injury induced by chemotherapy in lymphoma patients with positive serum label of hepatitis B virus (HBV). Methods Hepatic function (including ALT,AST,ALP, GGT and TBIL) were measured in 336 cases of lymphomapatients with positive serum label of HBV after two week chemotherapy. 119 cases of lymphoma patients with negative serum label of HBV were regarded as controls. Results Abnormal rates (38.39%) of hepatic function in positive serum label of HBV group were higher than that (19.33%) in negative serum label of HBV group ( P <0.01). Conclusion Hepatic function in positive label of HBV group is easily damaged after chemotherapy.