摘要
报告发病后６-１２ h内入ccu的27例急性心肌梗塞患者用日本产尿激酶150万 IU于30 min内静滴溶栓。按照临床评价，冠脉血管开通率为78%，5周病死率为7%，对照组为30%(P<0.05)，病死率减少77%;溶栓组发生重度心衰率为7%，对照组为30%(P<0.05)，两组有显著差异。溶栓组病人全部未用肝素，作者对此问题提出了自己的看法。
Objective：To study reduction mortality and complication s after thrombolysis in acute myocardial infarction(AMI).Methods：27 patients with AMI recei ved urokinase(made in Japan) 1 500 000 u with intravenous infusion within 30 mi nute for thrombolysis from November 1994 to August 1998.UK infusion was given a t<12 hours after the onset of the first symptoms. 27 patients of contrast group with AMI received conventional therapy.The patency of infarct-re lated coronary artery was assessed by clinical criteria.In order to avoid bleedi ng-especially intracranial hemorrhage,all 27 patients with thrombolysis were not used heparin,but given Aspirin 50 mg/d.Results:21 patients were successful repe rfuse and 6 failured after thrombolysis.The ratio of reperfusion was 78%.8 patien ts(30%) with severe heart failure occurred in the contrast group,and 2 patients(7%) in the thrombolysis.The five week mortality in patient with contrast group was 8 (30%) versus 2(7%) in thrombolysis group(P<0.01).The ratio of m ortality was reduced 77%.Our study showed that the effect of thrombolytic therapy was evident, saved 23 per 100 patients.Conclusion:Intravenous thrombolysis in acute myocardial infarction has affirmative effect for reduction mortality and complications.
