放疗与化疗同步治疗食管癌近期疗效观察

The observation of short-term effect of radiotherapy combiningchemotherapy for esophageal carcinoma

目的 :探索放疗与化疗同步联合治疗食管癌的近期疗效。方法 :对50例食管癌患者进行随机对照试验 ,25例采用DDP加5 Fu联合放疗同步治疗(实验组) ,25例单纯放疗(对照组)。两组均采用常规分割放疗 ,每次2.0Gy,总剂量60～70Gy。实验组放疗第1、22天同时开始化疗 ,DDP总量达240mg,5 Fu总量3.0g。结果 :实验组肿瘤完全消退所需放射剂量低于对照组(P<0.01) ;放疗结束后病变完全消失率高于对照组 ,分别为76 %和20%(P<0.05)。1年生存率分别为72 %和32%(P<0.05)。结论 :放化疗同步治疗食管癌有明显协同作用 ,虽毒副反应加重 。

Objective:To investigate short term effect of radiotherapy combining chemotherapy for esophageal carcinoma.Method:50 patients of esophageal carcinoma were divided randomly into two groups.The experimental group (25ptients)was treated with DDP and 5 Fu chemotherapy combining radiotherapy,the control (25 patiets) was treated with radiotherapy only.Both groups were treated with conventional radiotherapy,fractionated at 2.0Gy to total 60Gy.On the first and twenty second day of radiotherapy,combined chemotherapy was given concurrently in experimental group,total dose of DDP and 5 Fu were 240mg,3.0g respectively.Result:The radiation dose for tumor complete response of experimental group was less than that of control group (P<0.05).The rate of tumor complete response of experimental group was significantly higher than that of control group,which was 76% and 20% respectively (P<0.05).The 1 year survival was 72% and 32% respectively(P<0.05).Conclusion:Radiotherapy combining concurrent chemotherapy had significant synergism,the side effect aggravated,but could be tolerated by the patients.