小剂量阿糖胞苷和维甲酸治疗高危MDS25例疗效观察

ATRA and LD-Ara-c treatment for 25 cases withhigh risk myelodysplastic syndrome

目的 :研究高危MDS的治疗方法 ,观察小剂量阿糖胞苷(LD Ara c)和全反式维甲酸(ATRA)诱导治疗高危MDS的疗效。方法 :高危MDS25例 ,应用LD Ara c10 15mg/m2,每12小时1次皮下注射 ,21天一疗程 ,间隔10天～15天重复 ;ATRA30～60mg/d ,分3次口服。结果 :完全缓解9例(36%) ,部分缓解4例(16%) ,4例进步 ,8例无效 ,总有效率52 % ;10例(40 %)在治疗中或CR/PR后转变为急性白血病。结论 :LD Ara c和ATRA诱导治疗高危MDS确有明显疗效 ,无严重骨髓抑制 ,感染及出血轻 。

Objective:To observe the effects of all trans retinoic acid (ATRA) and LD Ara c induced therapy in high risk myelodysplastic syndrome (MDS);Methods:25 MDS patients were treated by LD Ara c and ATRA.Ara c 10 15 mg/m2 were given by hypodermic injection every 12 hours for 21 days,ATRA 30 60 mg/d tid per os.Results:9 cases had got complete remission(CR)(36%),4 cases partial remission (PR)(16%),4 cases improved,and 88 cases ineffective.10 cases turned into AML during treatment or after obtaining CR/PR.Conclusion:The results show that LD Ara c and ATRA induced therapy is an effective method in improving the patient prognosis.