消氮颗粒对慢性肾衰大鼠的实验研究

Experimental study of effect of Xiaodan Granules on renal function of rats with chronic renal failure

目的观察消氮颗粒对腺嘌呤所致大鼠慢性肾衰的影响。方法除正常组外,其他各组大鼠用腺嘌呤制备慢性肾衰模型。将模型大鼠随即分为低、中、高剂量(0.99,1.98,3.96 g·kg-1)消氮颗粒组和阳性对照组(给予尿毒清颗粒2.09 g·kg-1),灌胃治疗30 d,观察各组大鼠血肌酐(SCr)、尿素氮(BUN)及病理学的变化。结果与模型组比较,阳性对照组和3个剂量消氮颗粒组的血清SCr、BUN含量显著降低,肾脏组织的功能有所改善。结论消氮颗粒对腺嘌呤肾衰大鼠的肾功能有改善作用。

Objective To explore the effect of Xiaodan Granules on renal function of rats with chronic renal failure （CRF）induced by adenine. Methods Except for the normal group, the rats with CRF induced by adenine were randomly divivded into five groups： model group, low, medi- ate,high dosage （0. 99,1.98,3.96 g·kg^-1 ） of Xiaodan Granules group and positive control group with Niaoduqing Granules （2. 09g·kg^-1）. Corresponding drugs were given to these five groups for 30 days. The serum creatinine （SCr）,blood urea nitrogen （BUN） and pathology were investigated to find out differences among them. Results Compared with the model group, SCr and BUN in Xiaodan Granales and Niaoduqing Grahules groups were significantly decreased, and renal pathology have improved in all treated CRF rats. Conclusion Xiaodan Granules have definitely therapeutic effect on chronic renal failure of rats caused by adenine.