抗增殖蛋白与氧化应激

Prohibitin and Oxidative Stress

抗增殖蛋白为一种高度保守、分布广泛、功能多样的蛋白,由核基因编码,定位于线粒体内膜、细胞核、细胞膜和基质中,由于其参与多种生物学进程,已引起广泛关注。由于其在线粒体上的特殊定位、结构和功能,使其近年在与氧化应激功能相关的研究中开始逐渐成为新的热点。针对抗增殖蛋白与线粒体的研究,系统阐述其在氧化应激及相关疾病和老龄化过程中的重要作用,并对其应用前景作以展望。

Prohibitin （ PHB ） , a highly-conserved protein, widely distributed and functional diversity, is encoded by the nuclear genes and located in nucleus membranes, mitochondrial membrane substrates and matrixes. It has been paid high attention because of its participation in a variety of biological processes. Now it is becoming a new research hotpot, because the special position on the mitochondrial and its special structure and function on it. In accordance with the studies of the relation of PHB and mitochondrial, PHB＇s important role was systematically elaborated in oxidative stress and the related diseases and the process of ageing in this paper, and the PHB＇s prospect of application was also looked into the future.