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金黄色葡萄球菌SarA家族蛋白及其翻译后修饰 被引量：1

SarA Family Proteins and Its Post-Translational Modification in Staphylococcus aureus
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摘要 在金黄色葡萄球菌全基因组中发现了一类SarA类似的蛋白家族,是金黄色葡萄球菌生理和毒力主要的调控因子。MgA、SarA和SarZ等蛋白分子中半胱氨酸的磷酸化修饰或氧化还原修饰引起了蛋白质构象的变化,从而调节了金黄色葡萄球菌毒力因子的产生以及细菌对万古霉素的抗性。SarA家族蛋白具有同源性,蛋白翻译后修饰具有相似性,同时蛋白之间又相互作用。 A class of family proteins found in staphylococcus aureus genome is similar to SarA, it contributes to the main physiological and virulence of staphylococcus aureus, protein cysteine phosphorylation of MgA/SarA/SarZ family or Oxidation and reduction modification can caused the change of protein conformation, which regulates the virulence factor ofS. aureus and to vancomycin-resistant. SarA family proteins are homologous and interacted, and its post-translational modification is similar.
作者 吴睿睿 朱福兴
机构地区 华中农业大学植物科学与技术学院
出处 《生物技术通报》 CAS CSCD 北大核心 2013年第10期40-45,共6页 Biotechnology Bulletin
关键词 SarA家族蛋白 磷酸化 氧化还原修饰 MgrA SarZ Family proteins of SarA Phosphorylation Oxidation and reduction modification MgrA SarZ
分类号 R378 [医药卫生—病原生物学]
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参考文献32

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生物技术通报
2013年 第10期

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