双相障碍患者脑白质完整性的初步研究

Preliminary Studies of Cerebral White Matter Integrity in Bipolar Disorder Patient

目的:在弥散张量成像下,使用部分各向异性分数(fractional anisotropy,FA)及表观弥散系数(apparent diffusion coefficient,ADC)来探讨双相障碍患者相对于对照组脑白质完整性的差异。方法:采集15例双相障碍患者和15例健康志愿者的弥散张量成像数据,分别对每个被试的图像进行配准并进行定量计算,在得到可靠的FA和ADC后,使用SPM软件包分别对FA和ADC进行双样本t-检验。结果:①与对照组相比,双相障碍患者在胼胝体、左侧颞上回(体素=15)区域FA值降低,而在右侧小脑扁桃体、右侧枕叶、右侧豆状核壳部、右侧额叶、右侧顶叶、左侧颞叶(颞中回、颞上回(体素=47))、尾状核、右侧丘脑、左侧前额叶等区域FA值升高;②同时在右侧颞中回、前额叶中央沟附近、中央后回区域ADC值降低,而在胼胝体、左侧颞上回、右侧绒球小结叶区域ADC值升高。结论:双相障碍患者胼胝体连接左右半球的信息传递能力减弱,局部区域白质FA值升高,这可能是双相障碍患者思维奔逸、情感高涨、活动增加等精神活动增加而失去控制的原因。

Objective： By using fractional anisotropy （FA） and apparent diffusion coefficient （ADC）, the present study aimed to explore the differences of cerebral white matter integrity between bipolar disorder patients and normal controls. Methods： Diffusion tensor imaging data were obtained 15 patients with bipolar disorder and 15 healthy volunteers, re- spectively. After image registration and quantitative calculation, reliable FA and ADC maps were obtained. Finally, two- sample t-tests after data preprocessing were performed by using SPM software. Results： ①Compared with normal controls, bipolar disorder patients showed significantly decreased FA valuces in the corpus eallosum, and left superior temporal gyms （voxel=lS） and increased FA values in the Cerebellar tonsils, occipital lobe, putameu, frontal lobe, parietal lobe, and thalamus in the fight hemisphere, and the temporal lobe（superior temporal gyms, superior temporal gyrus（voxel=47）, eau- date nucleus, and prefrontal in the left hemisphere. ②Meanwhile, in the fight middle temporal gyms, near the central right postcentral and Sub-gyral, ADC value in the patients with bipolar disorder significantly decreased; in the central body of the corpus callosum, the left superior temporal gyrus and the right nodule, ADC value significantly increased. Conclusion： The reduced FA value in the corpus callasum suggest the information transfer between two hemispheres may be weakened in the biplar disorder. Increased FA values in regional brain may accounbt for flight of thought, hyperthymia and increased mental activities in bipolar disorder patients.