中药结合健康生活模式对多囊卵巢综合征肥胖患者体重的影响

Effect of Chinese Medicine Combined with Lifestyle Modification on Body Weight of Obese Patients with Polycystic Ovary Syndrome

目的:探讨中药结合健康生活模式对多囊卵巢综合征(PCOS)肥胖患者体重的影响。方法:60例合格受试者按照1∶1比例随机分为二甲双胍加健康模式组(A组)及中药加健康模式组(B组),接受2疗程规范治疗,观察2组患者身高、体重、腰围、臀围,计算体重指数(BMI)及腰臀比(WHR)。结果:48例患者完成整个临床观察(A组23例,B组25例)。治疗后A、B组患者BMI、WHR均有下降,组间比较,差异均无显著性意义(P>0.05)。治疗后,A组3例患者BMI恢复正常,Ⅱ度肥胖减少到4例;B组4例患者BMI恢复正常,Ⅱ度肥胖减少到4例,组间比较,差异无显著性意义(P>0.05)。体重减轻结果显示,A组显效5例,有效13例,无效5例,总有效率为78.3%;B组显效7例,有效10例,无效8例,总有效率为68.0%,2组间疗效比较,差异无显著性意义(P>0.05)。结论:中药结合健康生活模式可有效降低PCOS肥胖患者体重、BMI、WHR,从而起到治疗作用。

Objective. To observe the effect of Chinese medicine combined with Ifestyle modification on the body weight of obese patients with polycystic ovary syndrome（PCOS）. Methods. Sixty obese patients with PCOS were equally randomized into groups A and B. On the basis of lifestyle modification, group A was given metformin and group B was given Chinese medicine cycle therapy. After 2 courses of treatment, we examined the body height, body weight, waist circumference, hip circumference, and then calculated body mass index（BMI） and waist-hip ratio（WHR）. Results, There were 48 patients who finished the trial, 23 from group A and 25 from group B. After treatment, BMI and WHR were decreased significantly in groups A and B, but the differences were insignificant between the two groups（P〉0.05）. BMI recovered to the normal in 3 patients of group A and in 4 of group B, and relief of obesity II~ occurred in 4 patients of group A and in 4 of group B, the differences being insignificant between the two groups（P 〉 0.05）. According to the standard of loss of body weight, the re- sults showed that 5 cases（27.1%） were markedly effective, 13（56.5%） were effective, while 5 cases（21.7%） were ineffec- tive, the total effective rate was 78. 3% in group A; in group B, 7 cases（28.0%） were markedly effective, 10（40.0%） were effective, 8（32.0%） were ineffective, the total effective rate was 68.0%. There was no significant difference of body weight loss between the two groups（P 〉 0.05）. Conclusion, Chinese medicine combined with lifestyle modification is effective on decreasing body weight, 8MI and WHR of obese patients with PCOS.