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1型糖尿病患儿血清可溶性肿瘤坏死因子相关凋亡诱导配体水平的变化及意义 被引量：1

The Expression and Clinical Significance of Soluble Tumor Necrosis Factor-related Apoptosis inducing Ligand level in Serum of Children with Type 1 Diabetes Mellitus
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摘要 检测初发1型糖尿病患儿血清肿瘤坏死因子相关凋亡诱导配体(sTRAIL)、空腹血糖、糖化血红蛋白(HbA1c)和C肽水平,并进行相关性分析。结果显示:1型糖尿病患儿胰岛素治疗前、治疗3个月、6个月时血清sTRAIL水平显著低于正常对照组(P<0.05),治疗12个月时较治疗前明显上升,与对照组无显著差异。提示sTRAIL可能参与了儿童1型糖尿病的发病过程。
作者 苗静 辛颖
机构地区 中国医科大学附属盛京医院儿科
出处 《中国医科大学学报》 CAS CSCD 北大核心 2013年第10期939-941,共3页 Journal of China Medical University
关键词 肿瘤坏死因子相关凋亡诱导配体 可溶性TRAIL 1型糖尿病 儿童
分类号 R725.8 [医药卫生—儿科]
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参考文献14

  • 1Wiley SR,Schooley K,Smolak PJ,et al.Identification and characterization of a new member of the TNF family that induces apoptosis[J].Immunity,1995,3 (6):673-682.
  • 2The Expert Comminee on the Diagnosis and Classification of Diabetes Mellitus.Report of the expert committee on the diagnosis and classification of diabetes mellitus[J].Diabetes Care,1997,20(7):1183-1197.
  • 3Bemardi S,Norcio A,Toffoli B,et al.Potential role of TRAIL in the management of autoimmune diabetes mellitus[J].Curr Pharm Des,2012,18 (35):5759-5765.
  • 4Sanlioglu AD,Diricc E,Elpek O,et al.High levels of endogenous tumor necrosis factor-related apoptosis-indueing ligand expression correlate with increased cell death in human pancreas[J].Pancreas,2008,36(4):385-393.
  • 5Sanlioglu AD,Dirice E,Elpek O,et al.High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients[J].Pancreas,2009,38(2):154-160.
  • 6Sadarangani A,Kato S,Espinoza N,et al.TRAlL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract[J].Apoptosis,2007,12(1):73-85.
  • 7Dirice E,Sanlioglu AD,Kahraman S,et al.Adenovirus-mediated TRAIL gene (Ad5hTRAIL) delivery into pancreatic islets prolongs normoglycemia in streptozotocin-induced diabetic rats[J].Hum Gene Ther,2009,20(10):1177-1189.
  • 8Kang S,Park SY,Lee H J,et al.TRAIL upregulates decoy receptor 1 and mediates resistance to apoptosis in insulin-secreting INS-1 cells[J].Biochem Biophys Res Commun,2010,396(3):731-735.
  • 9Mellanby R J,Thomas D,Phillips JM,et al.Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4 +CD25+ Foxp3+ regulatory T cells[J].Immunology,2007,121 (1):15-28.
  • 10Mi QS,Lamhamedi-cherradi SE,Salojin KV,et al.Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice[J].Diabetes,2003,52 (8):1967-1975.

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中国医科大学学报
2013年 第10期

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