福州市妇女乳腺癌危险因素的病例对照研究

A Case-control Study on Risk Factors of Breast Cancer for Women in Fuzhou

[目的 ]探讨福州市女性乳腺癌的危险因素。 [方法 ]对近 2年在福州市各大医院进行手术并经病理确诊为乳腺癌的 145名患者开展 1∶ 1配对的病例对照研究。资料使用 Epi- Info软件和 SAS6 .0 4版软件进行统计分析。 [结果 ]单因素分析 ,达到统计学显著性水平的危险因素有乳腺良性疾病史、BMI指数高、初潮年龄早、肿瘤家族史、初产年龄大、流产次数多、未产年龄大和行经时乳房涨痛。哺乳和饮用井水是保护因素。条件 L ogistic回归分析显示初潮年龄早、乳腺良性疾病史、肿瘤家族史及流产次数多是乳腺癌的危险因素 ,而哺乳和饮用井水是保护因素。 [结论 ]福州市女性乳腺癌的危险因素是 :乳腺良性疾病史、初潮年龄早、肿瘤家族史及流产次数多。

Objective] To detect the risk factors of breast cancer for women in Fuzhou. [Methods] To study 145 cases with breast cancer by 1:1 match case control study. To analyze the data with the Epi Info and SAS 6.04 packages. [Results] In the one way analysis, the risk factors of breast cancer are history of benign breast diseases, high body mass index, early age at menarche, family history of carcinoma, late age at primiparity, high frequency of abortion, a large age at last parturition, and swell or pain in breast during menstruating. In conditional logistic regression model, early age at menarche, history of benign breast diseases, family history of carcinoma, high frequency of abortion are risk factors, while breast feeding and drinking well water are protective factors. [Conclusion] The risk factors of breast cancer for women in Fuzhou are history of benign breast diseases, early age at menarche, family history of carcinoma and high frequency of abortion.