中孕引产口服米非司酮前后子宫及胎盘血液动力学改变和胎盘超微结构的变化

The Changes of Placental Hemodynamics and infrastructure Pre and Post-administration of Miphistone in Intermediate Abortion.

目的:观察孕16～24周需终止妊娠者服用米非司酮前后UtA和UmA血流速度波型变化和胎盘微血管的改变,探讨米非司酮在引产过程中的作用环节。方法:30例对象口服米非司酮25mg,bid×3天,第4日上午加用米索前列醇200μg。服药前后检测UtA和UmA的PI、RI及S/D,并于胎盘母体面取材作电镜检查。结果:用药后UtA和UmA的PI、RI和S/D值均较用药前升高,其中UtA的RI,S/D和UmA的S/D升高值较用药前的数值差异显著(P<0.05),胎盘血管内皮细胞呈损伤性改变。结论:米非司酮能使UtA和UmA的RI和S/D值升高,导致子宫及胎盘循环受阻、缺血。

Objective:to observe the tachograme change of UtA and UmA, and the structure change of placental micrangium in gravidas of pregnancy 16-24 weeks pre and post-administration of Miphistone,to evaluate the effects of Miphistone in induced labor. Methods: 30 cases per os of Miphis-tone 25mg,bid× 3d,the 4th day per os Misoprogestrone 200μg,were analyzed the UtA,UmA.PI, RI and the ratio of S/D, and the placental structure of the mother side observed under the electron microscope after induced labor. Results : There was higher value that the UtA, UmA, PI, RI and the ratio of S/D post-administration is more than that of the pre-administration,RI,S/D of UtA and S/D of UmA were significantly higher after administration,there were obviously differences(P <0. 05). Conclusions :RI and S/D of UtA and UmA were raised by Miphistone,and the placental circulation was obstructed and ischemic.