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Galectin-3免疫组化检测对甲状腺滤泡性肿瘤良恶性鉴别的意义 被引量:1

Galectin-3 in differential diagnosis between benign and malignant thyroid follicular tumor
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摘要 目的 探讨Galectin-3在甲状腺滤泡性肿瘤中的表达,及其鉴别诊断良、恶性甲状腺滤泡性肿瘤的价值.方法 对120例甲状腺滤泡性癌及80例甲状腺滤泡性腺瘤应用免疫组织化学方法检测Galectin-3的表达.结果 Galectin-3表达阳性率在甲状腺滤泡性癌为84%,在甲状腺滤泡性腺瘤为19%(P<0.01).Galectin-3表达强阳性者,在甲状腺滤泡性癌占40%,而在甲状腺滤泡性腺瘤,无一例强阳性.结论 Galectin-3表达可作为鉴别甲状腺良、恶性滤泡性肿瘤的重要参考指标. Objective To analyze the expression of Galectin-3 in thyroid follicular tumors and its clinical significance in differential diagnosis between benign and malignant thyroid follicular tumor.Methods The expression of Galectin-3 in 120 cases of thyroid follicular carcinoma and 80 cases of thyroid follicular adenoma was detected by immunohistochemical technique.Results The expression rate of Galectin-3 in thyroid follicular carcinoma was significantly higher than that in follicular adenoma(84% vs 19%,P < 0.01).Strong positive expression of Galectin-3 was found in 40% cases of thyroid follicular carcinoma and no case of thyroid follicular adenoma.Conclusions The expression of Galectin-3 can be regarded as an important parameter for differential diagnosis between benign and malignant thyroid follicular tumor.
出处 《中华内分泌外科杂志》 CAS 2013年第5期424-425,共2页 Chinese Journal of Endocrine Surgery
关键词 甲状腺滤泡性肿瘤 免疫组织化学 基因表达 Thyroid neoplasms Immunohistochemistry Gene expression
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