四种清肠方法的临床效果对比观察

The observation of effects of four different intestinal preparation methods

目的比较四种不同清肠方法的清肠效果、肠道内气泡产生情况、不良反应发生情况及患者下一次服用意愿,探索快捷、有效、安全的清肠方法。方法选取240例准备做结肠镜检查的患者,随机分为四组:A组服用20%甘露醇溶液,B组服用聚乙二醇4000散剂,C组服用聚乙二醇4000散剂联合枸橼酸莫沙必利分散片,D组服用磷酸钠盐口服液。比较四组患者肠道清洁程度、肠道内气泡产生情况和不良反应发生情况。结果 C组和D组的清肠效果优于A组和B组,D组的不良反应发生率明显低于其余各组(P<0.05),四组的肠道内气泡产生率差异无统计学意义(P>0.05)。结论聚乙二醇联合莫沙必利及磷酸钠盐这两种清肠方法较理想,磷酸钠盐清肠不良反应发生率最低。

Objective To compare the effects of intestinal preparation,reverse drug reactions,bubbles and tolerability among 4 different intestinal preparation methods,in order to seek out simple fast and safe intestinal preparation methods.Methods Two hundred and forty patients undergoing colonoscopy were randomly divided into 4 groups with 60 cases in each group.Group A received mannital,group B received Macrogol 4000 powder for oral solution,group C received Macrogol 4000 powder for oral solution combined with Mosapride citrate dispersible tablets,group D received oral sodium phosphate.Effects of bowel cleansing,reverse drug reactions and bubbles were observed and compared.Results The intestinal cleanliness of group C and group D were superior to group A and group B.Among the four groups,group D has the lest rate of reverse drug reactions（P ＆lt; 0.05）.Four groups showed the similar rate of bubbles.Conclusion Both methods,no matter the combined use of Macrogol 4000 powder for oral solution and Mosapride citrate dispersible tablets,or oral sodium phosphate have better quality of bowel cleansing,and oral sodium phosphate has the lest rate of reverse drug reactions.