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家养动物数量性状全基因组关联研究进展——单标记回归分析策略 被引量：2

Research Progress of Genome-wide Association Study for Quantitative Traits in Farm Animals:Strategy of Single-marker Regression Analysis
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摘要 全基因组关联分析是一种旨在充分利用群体水平的连锁不平衡,以高密度SNP芯片为技术基础,在全基因组范围内定位影响表型性状的遗传因素的遗传分析方法。对群体分层的主要检测方法、基于单标记线性混合模型策略的GWAS分析方法研究进展及全基因组关联分析样本量的估计予以综述,为家养动物数量性状的主效QTC定位提供参考。 Genome-wide association study is a systematic approach to identifying the genetic factors influencing the phenotypic variation across the whole genomes by exploiting the linkage disequilibrium at the population level,based on a variety of high-density SNP chips.This review presented the advancement of the methods for detection of population stratification,different kinds of linear mixed models for GWAS in farm animals on the basis of single-marker analysis and the rough estimate of the sample size for GWAS.This review will help to idertify the major QTC underlying quantitative traits in farm arimals.
作者 郭家中 王小龙 刘小林
机构地区 四川农业大学动物科技学院 西北农林科技大学动物科技学院
出处 《家畜生态学报》 北大核心 2013年第8期1-5,共5页 Journal of Domestic Animal Ecology
基金 国家科技计划重大项目(2008AA101010 2011AA100307) 陕西省"13115"科技创新工程项目(2008ZDKG-11)
关键词 全基因组关联研究 群体混杂 单标记 样本量 genome-wide association study population confounding single marker sample size
分类号 S811.6 [农业科学—畜牧学]
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  • 1Risch N,Merikangas K.The future of genetic studies of complex human diseases[J].Science,1996,273(5281):1516-1517.
  • 2Reich D E,Lander E S.On the allelic spectrum of human diseases[J].Trends Genet,2001,17(9):502-510.
  • 3Wang W Y S,Barratt B J,Clayton D G,et al.Genome-wide association studies:theoretical and practical concerns[J].Nat Rev Genet,2005,6(2):109-118.
  • 4Klein R J,Zeiss C,Chew E Y,et al.2005.Complement factor H polymorphism in age-related Macular degeneration[J].Science,308(5720):385-389.
  • 5Abasht B,Lamont S J.Genome-wide association analysis reveals cryptic alleles as an important factor in heterosis for fatncss in chickcn F2 populations[J].Anim Genet,2007,38:491-498.
  • 6Daetwyler H D,Schenkel F S,Sargolzaei M,et al.A genome scan to detect quantitative trait loci for economically important traits in Holstein cattle using two methods and a dense single nuclcotide polymorphism map[J].J Dairy Sci,2008,91 (8):3 225-3 236.
  • 7Cole J B,Wiggans G R,Ma L,et al.Genome-wide association analysis of thirty one production,health,reproduction and body conformation traits in contemporary U.S.Holstein Cow[J].BMC Genomics,2011,12:408.
  • 8Gregersen V R,Conley L N,Sorensen K K,et al.Genomewide association scan and phased haplotype construction for quantitative traits loci affecting boar taint in three pig breeds[J].BMC Genomics 2012,13:22.
  • 9Karlsson E K,Baranowska I,Wade C M,et al.Efficient mapping of mendelian traits in dogs through genome-wide association[J].Nat Genet,2007,39:1321-1328.
  • 10Dorshorst B,Molin A M,Rubin C J,et al.A complex genomic rearrangement involving the Endothelin 3 locus cuases dermal hyperpigmentation in the chicken[J].PLoS Genet,2011,7(12):e1002412.

同被引文献72

  • 1兰蓉,朱兰,姚新荣,王鹏,邵庆勇,洪琼花.山羊产羔数全基因组关联分析[J].畜牧兽医学报,2015,46(4):549-554. 被引量：22
  • 2Wright S.Evolution in mendelian populations[J].Genetics,1931,16(2):97-159.
  • 3Falconer D S,Mackay T F C.Introduction to quantitative ge- netics[M],4th Edition.England:Longman,1996:129-140.
  • 4Lynch M,Walsh B.Genetics and analysis of quantitative traits[M].Sunderland,MA:Sinauer Associates,1998:65-71.
  • 5Carlborg 0,Haley C S.Epistasis:Too often neglected in com- plex trait studies?[J].Nat Rev Genet,2004,5(8):618-625.
  • 6Hill W G,Goddard M E,Visscher P M.Data and theory point to mainly additive genetic variance for complex traits[J].PLoS Genet,2008,4(2):el000008.
  • 7Breen M S,Kemena C,Vlasov P K,et al.Epistasis as the prima- ry factor in molecular evolution[J].Nature,2012,490(7421):535-538.
  • 8Hemani G,Knott S,Haley C.An evolutionary perspective on e- pistasis and the missing heritability[J].PLoS Genet,2013,9(2):el003295.
  • 9Phillips P C.Epistasis:The essential role of gene interactions in the structure and evolution of genetic systems[J],Nat Rev Genet,2008,9(11):855-867.
  • 10Haley C S,Knot S A.A simple regression method for mapping quantitative trait loci in line crosses using flanking markers[J].Heredity,1992,69(4):315-324.

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家畜生态学报
2013年 第8期

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