轻度认知功能障碍患者认知损害与血清脑源性神经营养因子水平的相关性

Association between Serum Brain-derived Neurotrophic Factor Level and Cognitive Impairment in Patients with Mild Cognitive Impairment

目的研究轻度认知功能障碍(mild cognitive impairment,MCI)患者认知损害与血清脑源性神经营养因子(brain derived neurotrophic factor,BDNF)水平的关系。方法从认知障碍门诊筛选MCI患者30例,正常对照老年人32例,采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测MCI患者的血清BDNF水平。结果 MCI的血清BDNF水平较正常对照组显著升高(P=0.025),MCI组中血清BDNF与简明精神状态量表(Mini-Mental State Examination Scale,MMSE)中的记忆力(r=-0.494,P=0.009)、语言能力(r=-0.399,P=0.039)呈负相关,与定向力、注意力和计算力、回忆能力无相关性;与临床痴呆量表(Clinical Dementia Rating Scale,CDR)总分呈正相关(r=0.476,P=0.012);与MMSE总分、全面衰退量表(Global Deterioration Scale,GDS)总分无相关性。结论 MCI患者的BDNF水平显著升高,提示BDNF可能参与MCI认知损害的病理生理过程。

Objective To investigate the relationship between cognitive function and brain-derived neurotrophic factor （BDNF） in mild cognitive impairment and healthy elders. Methods From the community society, we selected 30 samples of mild cognitive impairment （MCI） and 32 control samples. The cognitive function was evaluated by neuropsychological test and the level of BDNF was tested by enzyme-linked immunosorbent assay （ELISA）. Results Compared to the control group, the level of BDNF in MCI patients was signiifcantly increased than healthy elders （P=0.025）. Also, the level of BDNF in MCI patients was negatively correlated to memory （r=-0.494, P=0.009） and language （r=-0.399, P=0.039） of Mini-Mental State Examination Scale, and positively correlated to the scores of Clinical Dementia Rating Scale （r=0.476,P=0.012）. Conclusion The increased level of BDNF in MCI patients showed that BDNF may be involved in the pathophysiology of cognitive impairment.