自发性颈部动脉夹层与缺血性卒中

Spontaneous Cervical Artery Dissection and Ischemic Stroke

自发性颈部动脉夹层(spontaneous cervical artery dissection,SCAD)是青中年缺血性卒中的主要病因之一。SCAD是遗传、环境、感染等多因素疾病,其中,血管相关危险因素与SCAD的关系仍然存在争论。研究显示,SCAD引起的缺血性卒中以血栓栓塞机制为主,因此,抗凝、抗血小板治疗是SCAD的主要治疗方式,但目前尚缺乏随机对照试验对两种治疗方式的疗效进行对比。同时,多项单中心病例研究证实了血管内支架治疗SCAD的有效性和安全性。

Spontaneous cervical artery dissection （SCAD） is one of the major cause of ischemic stroke in young and middle-aged patients. It is a multifactorial disease involving inheritance, environment, infection in which it is still controversy about the relationship between SCAD and vascular risk factors. Available evidence strongly favors embolism as the most common cause for ischemic stroke. Anticoagulation and antiplatelet are the main treatment options, but randomized trials are lacking to compare both options. There are several single-center studies to evaluate the validity and safety of endovascular stent therapy for SCAD. Most of SCAD has favorable prognosis.