胃镜检查中应用格拉司琼的体会

The granisetron application experience in gastroscopy

目的研究格拉司琼在胃镜检查中的止呕效果和安全性。方法随机将120例胃镜检查患者分为观察组和普通组,观察组60例除常规术前准备外,给予格拉司琼3mg静脉注射,普通组60例予常规操作,比较两组胃镜检查中患者呕吐次数、胃蠕动次数、患者感受,检查前、中、后血压、心率和血氧饱和度的变化。结果呕吐次数、胃蠕动次数、患者感受情况等指标,两组比较有显著性差异(P<0.01);两组分别比较检查前、中、后血压、心率和血氧饱和度,观察组患者检查前、中、后血压、心率和血氧饱和度比较差异无显著性(P>0.05),而普通组在检查中与检查前相比,有明显的变化。术中监测发现,普通组检查中收缩压和舒张压增高,心率加快,升高程度分别为24.7%,22.0%,25.0%,与检查前比较差异有统计学意义。结论格拉司琼静注用于胃镜检查,可减少患者不适感,利于胃镜的操作检查,值得推广使用。

Objective To study the granisetron in gastroscopy antiemetic efficacy and safety. Methods 120 patients with gas- troscopy randomly were divided into observation group and the normal group, Observation group ,60 cases in addition to routine preop- erative preparation,the granisetron 3mg given intravenously, Ordinary group of 60 patients treated with conventional operations, Pa- tients in gastroscopy were compared frequency of vomiting, gastric motility times,the patient experience, and the blood pressure heart rate and oxygen saturation changes before, during and- after treating. Results Frequency of vomiting, gastric motility times, patients feel the situation and so on, the two groups were significantly different （P 〈 0.01 ） ;The blood pressure, heart rate and oxygen satura- tion were compared In each group before, during and after treating, observation group had no significant difference （ P 〉 0. 05 ） , While the ordinary checking compared with before, a significant change, it＇s found during gastroscopy in ordinary group systolic and dias- tolic blood pressure increased, accelerated heart rate. Higher levels were 24. 7% ,22.0% ,25.0% , Compared With before the exami- nation, difference was statistically significant. Conclusion intravenous the granisetron in endoscopy, Can reduce patient discomfort, which will help gastroscopy operation checks and it should be introduced.