血清总碱性磷酸酶和骨特异性碱性磷酸酶与非小细胞肺癌骨转移的相关性

Relationships among the levels of serum total alkaline phosphatase, bone-specific alkaline phosphatase and bone metastasis in patients with non-small cell lung cancer

目的探讨血清总碱性磷酸酶（tALP）和骨特异性碱性磷酸酶（bALP）与非小细胞肺癌（NSCLC）骨转移的相关性。方法分析湖北省新华医院2009年9月至2011年9月收治的30例NSCLC骨转移患者和30例NSCLC无骨转移患者血清标本，分别采用酶免疫荧光法和电化学发光法检测血清tALP和bALP水平。结果NSCLC骨转移组血清tALP和bALP均高于无骨转移组[（158±13）U／L比（69±12）U／L，（34±7）μg／L比（12±4）μg／L]（P〈0。05）。血清tALP水平升高判断NSCLC的灵敏度为63．3％，特异度为70．0％；血清bALP升高判断骨转移的灵敏度为86．7％，特异度为83．3％。结论血清tALP和bALP水平对NSCLC骨转移的诊断具有重要的参考价值。

Objective To explore the correlation between bone metastasis and the serum levels of total al- kaline phosphatase （tALP） and bone-specific alkaline phosphatase （bALP） in patients with non-small cell lung cancer（NSCLC）. Methods Thirty cases with NSCLC and 30 cases with non- bone metastasis were selected in our hospital from September 2009 to September 2011. The serum level of tALP and bALP were detected using enzyme immunofluorescence and electrochemiluminescence. Results The levels of serum tALP and bALP in patients of bone metastasis with NSCLC were higher than those without bone metastasis [ （158 ± 13 ）U/L vs （69 ± 12）U/L, （ 34 ± 7 ） μg/L vs （ 12 ± 4 ） μg/L ] （ all P 〈 0.05 ）. Sensitivity and specificity of elevated serum tALP levels on diag- nosis of bone metastases of NSCLC was 63.5% , 70.0% ,respectively; sensitivity and specificity of elevated serum bALP on diagnosis of bone metastases was 86.7%, 83.5%, respectively. Conclusion The levels of tALP and bALP have important diagnostic value in NSCLC with bone metastasis.