医院2011-2013年精神障碍住院患者用药情况

Investigation of drug use of hospitalized patients with mental disorder for 3 years

目的分析2011-2013年精神障碍住院患者精神药物的使用情况及临床用药情况。方法采用一日法对上海交通大学医学院附属精神卫生中心闵行院区2013年4月1日住院精神障碍患者1371例的精神药物应用状况进行调查，并与2012年4月1日和2011年4月1日的数据进行比较。结果（1）典型抗精神病药用量稳定，非典型抗精神病药中利培酮使用频率由2011年的21．1％降到至2013年的17．1％，而阿立派唑由2011年的11．2％升到至2013年的14．9％。②选择性5羟色胺再摄取抑制剂（SSRI）仍占据抗抑郁剂首位（61．5％），而新型抗抑郁剂米氮平用量逐年上升。③佐匹克隆在镇静催眠药使用中排名第一。结论新型药物临床应用比例正逐年上升，多样性、安全性已成为目前精神疾病临床用药的趋势。

Objective To observe the alteration of clinical application of psyehotropic drug therapy in re- cent three years. Methods We used one day time point survey to investigate pharmaeotherapy status of 1371 inpa- tient mental disorder patients at Shanghai Mental Health Center（ Minhang campus）. Results ①The use of typical antipsyehotics was stable; among atypical antipsyehotics, the use of risperidone was decreased from 21.1% in 2011 to 17.1% in 2013, while the use of aripiprazole was increased from 11.2% in 2011 to 14.9% in 2013. ② Selec- tive serotonin reuptake inhibitors（SSRI） was still the first choice among antidepressant agents（61.5% ）, while the new antidepressant mirtazapine dosage was increased year by year. ③ Zopiclone became the top-rank medicine a- mong the sedative-hypnotic. Conclusions The use of new drugs is increasing year by year. Diversity and safety have now become the trend in tho selection of antipsychotics