期刊文献+

^(131)I-全身扫描联合血清甲状腺球蛋白测定在分化型甲状腺癌患者随访中的意义 被引量:2

下载PDF
导出
摘要 目的探讨血清甲状腺球蛋白(thyroglobulin,Tg)测定和131I-全身扫描(131I-wholebody scan,WBS)在分化型甲状腺癌(differentiated thyroid carcinoma,DTC)患者131I治疗随访中的意义。方法于首次治疗前,治疗后第5d、3个月,对我科进行131I治疗的56例DTC患者进行血清Tg测定和131I-WBS。结果 131I治疗前,131I-WBS显示51例残留甲状腺或转移灶,其血清Tg均>11mg/L;余5例未发现复发或转移,4例血清Tg<11mg/L,1例血清Tg>11mg/L。131I治疗后第5d,3例发现浓聚131I转移灶较治疗前增多。131I治疗后3个月,33例131I-WBS显像未见颈部存在明显的131I摄取,而且未见任何其他部位的异常131I摄取灶,Tg<11mg/L;18例131I-WBS显像见颈部存在明显的131I摄取,但未见任何其他部位的异常131I摄取灶,15例Tg>11mg/L,3例Tg<11mg/L,未见明显升高;5例131I-WBS显像见明显异常131I摄取病灶;Tg>11mg/L。结论 131I-WBS联合血清Tg测定在131I治疗DTC随访中具有重要的作用,可提高转移灶的检出率。
作者 梁秀利
出处 《福建医药杂志》 CAS 2013年第5期125-127,共3页 Fujian Medical Journal
  • 相关文献

参考文献8

  • 1Lind P.131 I whole body scintigraphy in thyroid cancer patients[J].QJ NuclMed,1999,43 (3):188.
  • 2Kim T Y,Kim W B,Kim E S,et al.Serum thyoglobulin levels at the time of 131 I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low-risk patient with differentiated thyroid carcinoma[J].J Clin Enclocrinol metab,2005,90 (3):1440-1445.
  • 3Sawka A M,Brierley J D,Tsang R W,et al.An updated systematic review and commentary examining the effectiveness of radioactive iodine remnant ablation in well-differentiated thyroid cancer[J].Endocrinol Metab Clin North Am,2008,37 (2):457-480.
  • 4Heemstra K A,Lin Y Y,Stokkel M,et al.Serum thyoglobbulin concentrations predict disease-free yemission and death in differentiated thyroid carcinoma[J].Clinn docrinol (Oxf),2007,67 (3) 58-64.
  • 5Makarewicz J,Adamczewski Z,Rutkowski A,et al.An evaluation of the value of first thyroglobulin determination in the diagnostics of metastases immediately following differentiated thyroidcarcinoma surgery[J].Endokrynol Pol,2006,57 (4):370-373.
  • 6龙冰,潘明志.血清甲状腺球蛋白测定及其临床价值[J].人人健康:医学导刊,2008(4):6-7. 被引量:2
  • 7潘明志,田蓉.Tg阳性与诊断剂量^(131)I-WBS阴性甲癌患者的处理策略研究[J].华西医学,2005,20(2):337-337. 被引量:7
  • 8张志祥,郑岚,官靖华,等.血清甲状腺球蛋白测定和131碘全身显像在131碘治疗分化型甲状腺癌随访的临床价值[J].中华现代影像学杂志,2010,2 (7):221-222.

二级参考文献7

  • 1Pacini F,Agate L,Elisei R,et al.Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic(131)I Whole body scan:comparison of patients treated with high(131)I activities versus untreated patients[J].J Clin Endocrinol Metab,2001,86(9):4092-7.
  • 2Pacini F,Lippi F,Formica N,et al.Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobul in levels[J].J Nucl Med 1987,28(12):1888-91.
  • 3Clark OH,Hoelting T.Management of patients with differentiated thyroid cancer who have positiveserum thyroglobul in levels and negative radioiodine scans[J].Thyroid,1994,4(4):501-5.
  • 4Schlumberger M,Mancusi F,Baudin E,et al.131I therapy for elevated thyroglobulin levels[J].Thyroid,1997,7(2):273-6.
  • 5McDougall IR.131I treatment of 131I negative whole body scan,and positive thyroglobulin in differentiated thyroid carcinoma:what is being treated[J].Thyroid,1997,7(4):669-72.
  • 6Fatourechi V,Hay ID.Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases:including comments on the role of serum thyroglobul in monitoring in tumor survei llance[J].Semin Nucl Med,2000,30(2):107-14.
  • 7de Keizer B.Koppeschaar Hp,Zelissen PM,et al.Efficacy of high therapeutic doses of iodine-131 in patients with differentiated thyroid cancer and detectable serum thyroglobulin[J].Eur J Nucl Med,2001,28(2):198-202.

共引文献8

同被引文献14

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部