摘要
由心肌细胞分泌的一种具有生物活性的多肽vasostatin-1可非竞争性抑制肾上腺素受体,具有负性肌力、抗心肌缺血-再灌注损伤和抗心律失常作用。血浆vasostatin-1水平与急症患者预后相关,与冠心病患者冠状动脉存在病变和严重程度相关。本文综述vasostatin-1的生理作用、作用机制及其在临床预后判断中的价值。
Vasostatin-l（VS-1） is a biological active peptides secreted by the myocardial cells. VS-1 can loncompetitively inhibit Badrenergic receptor, and has the function of negative inotropic, anti-myocardial ischemia- ~eperfusion injury and anti-arrhythmic effects. Plasma VS-1 concentration is interrelated with acute disease. In addition, VS-1 is concerned with the presence and severity of coronary artery disease in patients with coronary artery disease. This ~ eview describes the physiological role, mechanism and clinical prognostic value ofVS-1.
出处
《世界临床药物》
CAS
2013年第10期619-622,共4页
World Clinical Drug
