五风藤的化学成分研究(英文)

Phytochemical Study on Holboellia latifolia

从五风藤的地上部分95%乙醇提取物中首次分离得到12个化合物,应用波谱方法及与已知品对照的手段鉴定它们为:lup-20(29)-en-3-one(1),羽扇豆醇(2),β-谷甾醇(3),齐墩果酸(4),乌苏酸(5),β-胡萝卜苷(6),五加苷K(7),hederagenin3-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside(8),β-萘乙酸(9),3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-α-L-arabinopyranosy1 oleanolic acid 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(10),3-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl oleanolic acid(11),3-O-(β-D-glucopyranosiduronic acid)-oleanolic acid 28-O-β-D-glucopyranosyl ester(12).体外细胞毒活性筛选结果表明化合物7和8具有较强的细胞毒活性.

Twelve compounds were isolated from the 95％ ethanol extract of the aerial part of medicinal herb Holboellia latifolia for the first time.On the basis of spectral data or comparison with authentic samples,they were characterized to be lup-20 （29）-en-3-one （1）,lupeol （2）,β-sitosterol （3）,oleanolic acid （4）,ursolic acid （5）,β-daucosterol （6）,Eleutheroside K （7）,hederagenin3-O-α-L-rhamnopyranosyl-（1 →2）-α-L-arabinopyranoside （8） 2-（naphthalen-1-yl）acetic acid （9）,3-O-α-L-rhamnopyranosyl-（1→2）-[β-D-glucopyranosyl-（1→3）]-α-L-arabinopyranosy1 oleanolic acid 28-O-α-L-rhamnopyranosyl-（1→4）-β-D-glucopyranosyl-（1 →6）-β-D-glucopyranosyl ester （10）,3-O-α-L-rhamnopyranosyl-（1→2）-O-β-D-gluoopyranosyl-（1 →2）-α-L-arabinopyranosyl oleanolic acid （11）,3-O-（β-D-gluoopyranosiduronic acid）-oleanolic acid 28-O-β-D-glucopyranosyl ester （12）.Compounds 7 and 8 showed Cytotoxic activity in vitro.