膜相关性鸟苷酸激酶与脑缺血

Membrane-associated guanylate kinases and cerebral ischemia

膜相关性鸟苷酸激酶（membrane associated guanylate kinase,MAGUK）是一类突触后致密蛋白（postsynaptic density,PSD）,定位于突触后膜的突触后致密区,包括PSD-95、SAP-102、PSD-93和SAP-97.MAGUK家族成员含有多个蛋白结合位点,这些特殊的结合位点负责介导多种信号的转导.MAGUK参与中枢神经系统疾病发生和发展机制,已成为神经科学研究的热点.文章简要综述了MAGUK在缺血性脑损伤中的作用.

Membrane-associated guany late kinases （MAGUKs） is a class of postsynaptic density proteins （PSDs） in the postsynaptic dense of the postsynaptic membrane, including PSD-95, SAP-102, PSD-93, and SAP-97. MAGUK family members contain several protein binding sites, and these special binding sites are responsible for mediating a variety of sigaal transduction. MAGUKs participate in the occurrence and development mechanims in central nervous system diseases, and has become a topic of general interest of neuroscience. This article briefly reviews the roles of MAGUKs in ischemic brain injury.