靛胭脂-美蓝双重染色法诊断早期胃癌的临床价值

Clinical value of indigocarmine-methylene blue staining in the diagnosis of early gastric cancer

目的探讨内镜下靛胭脂-美蓝双重染色法对早期胃癌及癌前病变的临床诊断价值。方法常规内镜检查发现可疑病灶的180例患者随机分为观察组(90例)和对照组(90例),观察组患者实施靛胭脂-美蓝双重染色,观察结果并组织活检;对照组患者行常规活检。结果观察组患者检测出早期胃癌12例,检出率为13.3%,检测出萎缩和(或)肠化28例,不典型增生22例,癌前病变的检出率为55.6%。对照组患者检测出早期胃癌5例,检出率为5.6%,检测出萎缩和(或)肠化18例,不典型增生13例,癌前病变的检出率为34.4%。差异有统计学意义(P<0.05)。结论内镜下靛胭脂-美蓝双重染色法可明显提高早期胃癌及癌前病变的检出率,且方便安全,值得临床推广应用。

Objective To investigate clinical value of indigocarmine-methylene blue staining in the diagnosis of early gastric cancer and precancerous lesions. Methods 180 patients with suspicious lesions detected by conventional endoscopy were randomly evenly divided into observation group and control group, the observation group received indigocarmine-metbylene double staining, and the control group routine biopsy. Results In observation group, there were 12 cases of early gastric cancer, the detection rate was 13.3% , and 28 cases of atrophy and （or） intestinal metaplasia and 22 cases atypical hyperplasia, the detection rate of precancerous lesions was 55.6%. In the control group, there were 5 cases of early gastric cancer, the detection rate was 5.6% ,and 18 cases of atrophy and （or） intestinal metaplasia,13 cases atypical hyperplasia, the detection rate of precancerous lesions was 34.4%. There was statistically difference （P 〈 0. 05 ）. Conclusions Endoscopic indigocarmine-methylene blue double staining method can signfificanfly improve the detection rate of early gastric cancer and precancerous lesions, it is safe and convenient, worthy of clinical application.