摘要
目的探讨联合化疗方案PDF即紫杉醇(PTX)+顺铂(DDP)+5-氟尿嘧啶(5-Fu)治疗晚期胃癌的临床疗效情况和安全性。方法入选2008年1月至2010年12月期间晚期胃癌患者80例,随机分为治疗组(40例)和对照组(40例)。对照组患者采用5-Fu治疗。治疗组患者采用PTX(135mg/m^2)静脉滴注3h,第1天;DDP(25mg/m^2)静脉滴注,第1—3天;5-Fu(750mg/m^2)静脉滴注,第1~5天,28天为1个化疗周期。2个周期后分析两组患者的疗效和不良反应。结果治疗组患者中,完全缓解(CR)8例,部分缓解(PR)10例,稳定(SD)15例,进展(PD)7例,临床有效率为45.0%,临床受益率为82.5%,明显高于对照组。治疗组患者的不良反应主要是骨髓抑制和消化道反应,症状较轻,不良反应明显低于对照组。结论采用联合化疗方案治疗晚期胃癌可提高疗效,且不良反应较轻,值得临床上推广。
Objective To investigate the efficacy and toxic reaction of combination of paclitaxel, cisplantin and 5-fluorouracil for treatment of advanced gastric carcinoma. Methods Eighty patients with advanced gastric cancer were treated with PTX 150 mg/m2dropping 3 hours on day 1, DDP 20 mg/m2 dropping on day 1 to3,5-Fu 750 mg/m2 dropping on day 1 to 5. The regimen was repeated every 4 weeks. The efficacy was evaluated after 2 cycles. Results The total effective rate of test group was 82. 5% in the 40 patients with advanced gastric cancer, including 8 cases C R, 10 cases PR, 15 cases SD,7 cases PD. The main toxicity were myelosuppression and alimentary canal reactions. Conclusions The results indicate that paclitaxel combined with cisplantin and 5-fluorouracil for treatment of advanced gastric carcinoma is safe and effective. It is worthy of clinical promotion.
出处
《中国肿瘤临床与康复》
2013年第10期1117-1119,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃肿瘤
紫杉醇
顺铂
5氟尿嘧啶
药物疗法
Stomach neoplasms
Paclitaxel
Cisplantin
5-fluorouracil
Drug therapy