卵巢核分裂象活跃的富于细胞性纤维瘤临床病理分析

Clinicopathological analysis of mitotically active cellular fibroma in ovary

目的探讨卵巢核分裂象活跃的富于细胞性纤维瘤（mitoticallyactivecellularfibroma，MACF）的临床病理学特征。方法观察2例MACF的临床资料、组织学形态、免疫表型，并复习相关文献。结果2例MACF患者临床表现良性。瘤细胞梭形，非常丰富，交叉呈束或漩涡状、席纹状排列，轻度异型，核分裂象4—7个／10HPF，无病理性核分裂象。出血水肿边缘瘤细胞异型明显伴有退变。结论MACF是一组卵巢的富于细胞的纤维性肿瘤，核分裂象≥4个／10HPF，缺乏核的显著异型，临床表现良性。文献报道仅少数病例复发，提示MACF具有低度恶性潜能。

Purpose To study the clinicopathological characteristics of mitotically active cellular fibroma（MACF）. Methods Clini- cal and pathological examination and immunohistochemistry were reported in 2 cases of MACF, and the related literatures were re- viewed. Results The clinical manifestations were benign. The tumors were hypercellular, composed of intersecting bundles of spindle cells, sometimes distributed as whirlpoo＇t or a storiform pattern. The mitotic count ranged from 4- to 7 MFs/10 HPF, No abnormal MFs were identified in two cases, and nuclear atypia were not severe. On the edge of edema and hemorrhagic area, the tumor cells were sig- nificant atypia associated with degeneration. Conclusions Ovarian MACF is a group of benign tumor with low malignant potential like as CF, because of the occasionally recurrent in the literature. Our findings indicate that MACF is a cellular fibromatous neoplasm with a mitotic count of ≥4 MFs/10 HPF and bland nuclear features.