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组织因子途径抑制物-2基因与非小细胞肺癌关系的研究进展 被引量：1

Research progress of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer
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摘要 组织因子途径抑制物-2（TFPI-2）是一种广谱的丝氨酸蛋白酶抑制物,可抑制包括纤溶酶、胰蛋白酶、基质金属蛋白酶在内的多种蛋白酶.TFPI-2可通过维持细胞外基质的完整、调节肿瘤血管生成、调控肿瘤细胞凋亡等机制调节非小细胞肺癌的侵袭转移,并成为肿瘤基因治疗的新靶点. Tissue factor pathway inhibitor-2 （TFPI-2） that inhibits plasmin,trypsin and matrix metalloproteinases is a broad-spectrum inhibitor of serine proteinase.TFPI-2 can accommodate the invasion and metastasis of human non-small-cell lung cancer by maintaining the integrity of extracellular matrix and regulating the angiogenesis and apoptosis of tumor cells.It has been a new target for gene therapy of cancers.
作者 梁江水(综述) 董永强 殷桂林(审校)
机构地区 南方医科大学武汉临床医学院广州军区武汉总医院心胸外科
出处 《肿瘤研究与临床》 CAS 2013年第10期714-716,共3页 Cancer Research and Clinic
基金 武汉市青年科技晨光计划（201050231090）
关键词 癌 非小细胞肺 组织因子途径抑制物-2基因 Carcinoma, non-small-cell lung Tissue factor pathway inhibitor-2 gene
分类号 R737.25 [医药卫生—肿瘤]
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参考文献27

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二级参考文献44

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共引文献14

同被引文献16

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肿瘤研究与临床
2013年 第10期

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