脑电双频指数在神经内科重症病房脑损伤患者转归中的预测价值

Prognostic evaluation of bispectral index in patients with acute brain injury in neurological intensive care unit

目的:研究脑电双频指数(BIS)对脑损伤患者转归的预测价值。方法:选取脑损伤伴有意识障碍的患者73例,应用BIS检查动态观察意识障碍程度的变化,同时进行格拉斯哥昏迷评分(GCS),观察2个月的预后。根据预后的意识水平分为死亡组、意识障碍组和清醒组,分析BIS值和预后的关系,GCS评分与BIS的相关性。结果:死亡组、意识障碍组、清醒组的BIS值分别为35.3±24.9、54.8±16.6、68.4±14.7;预后越差,BIS值越低,预后的意识水平与BIS值具有线性相关(χ2=11.090,P<0.01),BIS与GCS评分呈明显正相关(r=0.701,P<0.01)。结论:BIS与脑损伤程度具有良好的相关性,BIS监测在评估NICU脑损伤患者昏迷程度和预测转归上有重要意义。

Objective：To evaluate the prognostic value of bispectral index （BIS） monitoring in patients with acute brain injury in an neurological intensive care unit （NICU）.Methods：A total of 73 comatose patients with acute brain injury in NICU were enrolled.BIS was continuously monitored during their stay in the NICU.Meanwhile the neurological status of the patients was measured with Glasgow coma scale （GCS）.The prognosis was observed for two months.Patients were divided into dead group,unconscious group and conscious group according to the prognosis.The correlation between BIS and prognosis was analyzed.We also analyzed the correlation between BIS values and corresponding GCS.Results：BIS values were 35.3 ± 24.9,54.8 ± 16.6,68.4 ± 14.7 in dead group,unconscious group and conscious group respectively.By linear Chi-square test,death,unconsciousness and consciousness rate were related to BIS （x2 =11.090,P ＜ 0.01）.There was a positive correlation between BIS values and GCS （r =0.701,P ＜ 0.01）.Conclusion：BIS has a significant correlation with the severity of brain injury,and it is useful to predict the outcome of patients with acute brain injury in NICU by BIS monitoring.