病原细菌糖蛋白研究进展

Protein glycosylation in pathogens: research progress

蛋白糖基化一度被认为只存在于真核生物中,但近年越来越多的研究显示,无论是N-连接糖基化还是O-连接糖基化都同样存在于原核微生物中,其中就包括一些病原菌。糖蛋白的存在对这些病原菌的生命过程至关重要,研究者希望通过对病原菌糖蛋白的研究,探索出新的方式来预防及治疗由相关病原菌引发的疾病。该文对一些重要病原菌内糖蛋白的研究进展进行了综述。

Glycosylation used to be thought to be restricted to eukaryotes; however, there have been increasing reports ot both N-linked and O-linked protein glycosylation pathways in prokaryotes, including some pathogenic bacteria. The presence of glycoprotein is vital for life processes of these pathogens. Researchers hope to find new approaches to the prevention and treatment of diseases caused by related pathogens by studying their glycoprotein. Some important progress in glycoprotein research on pathogens was reviewed in this papar.